In vitro study of the mesenchymal stem cells-conditional media role in skin wound healing process: A systematic review

被引：8
作者：
Heydari, Mohammad Bagher [1 ]
Ghanbari-Movahed, Zahra [2 ]
Heydari, Maryam [3 ]
Farzaei, Mohammad Hosein [4 ]
机构：
[1] Kermanshah Univ Med Sci KUMS, Taleghani Hosp, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran
[3] Zabol Univ Med Sci, Dept Pharm, Zabol, Iran
[4] Kermanshah Univ Med Sci, Med Technol Res Ctr, Hlth Technol Inst, Kermanshah 6734667149, Iran
来源：
INTERNATIONAL WOUND JOURNAL | 2022年 / 19卷 / 08期
关键词：
conditional media; mesenchymal stem cells; skin; wound healing; STROMAL CELLS; REGENERATIVE MEDICINE; INFLAMMATORY CELLS; SECRETORY FACTORS; GROWTH-FACTORS; REPAIR; PROLIFERATION; MIGRATION; KERATINOCYTES; MECHANISMS;
D O I：
10.1111/iwj.13796
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mesenchymal stromal cell (MSC)-conditioned medium (CM) offers a potential opportunity in the skin wound healing treatment. In this systematic review, an overview of the knowledge on this topic has been provided. A multistep search of the PubMed, Scopus and Science Direct database has been performed to identify papers on MSCs-conditional media used in skin wound healing. Eligibility checks were performed based upon predefined selection criteria. Of the 485 articles initially identified, consequently, only 96 articles apparently related to MSC-conditional media were initially assessed for eligibility. Finally, the 32 articles, strictly regarding the in vitro use of MSCs-conditional media in skin wounds, were analysed. The information analysed highlights the efficacy of MSCs-conditional media on skin wound healing in vitro models. The outcome of this review may be used to guide pre-clinical and clinical studies on the role of MSCs-conditional media in skin wound healing.
引用
收藏
页码：2210 / 2223
页数：14
相关论文
共 50 条
  • [41] The Role of Paracrine Regulation of Mesenchymal Stem Cells in the Crosstalk With Macrophages in Musculoskeletal Diseases: A Systematic Review
    Xu, Hongtao
    Lee, Chien-Wei
    Wang, Yu-Fan
    Huang, Shuting
    Shin, Lih-Ying
    Wang, Yu-Hsuan
    Wan, Zihao
    Zhu, Xiaobo
    Yung, Patrick Shu Hang
    Lee, Oscar Kuang-Sheng
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
  • [42] The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study
    El Sadik, Abir O.
    El Ghamrawy, Tarek A.
    El-Galil, Tarek I. Abd
    [J]. PLOS ONE, 2015, 10 (09):
  • [43] Mesenchymal stem cells pretreated with proinflammatory cytokines accelerate skin wound healing by promoting macrophages migration and M2 polarization
    Liu, Chenyang
    Lu, Yichi
    Du, Pan
    Yang, Fengbo
    Guo, Peng
    Tang, Xiaoyu
    Diao, Ling
    Lu, Guozhong
    [J]. REGENERATIVE THERAPY, 2022, 21 : 192 - 200
  • [44] Mesenchymal stem cells ameliorate impaired wound healing through enhancing keratinocyte functions in diabetic foot ulcerations on the plantar skin of rats
    Kato, Jiro
    Kamiya, Hideki
    Himeno, Tatsuhito
    Shibata, Taiga
    Kondo, Masaki
    Okawa, Tetsuji
    Fujiya, Atsushi
    Fukami, Ayako
    Uenishi, Eita
    Seino, Yusuke
    Tsunekawa, Shin
    Hamada, Yoji
    Naruse, Keiko
    Oiso, Yutaka
    Nakamura, Jiro
    [J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2014, 28 (05) : 588 - 595
  • [45] Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro
    Sherman, Amanda B.
    Gilger, Brian C.
    Berglund, Alix K.
    Schnabel, Lauren V.
    [J]. STEM CELL RESEARCH & THERAPY, 2017, 8
  • [46] Role of Mesenchymal Stem Cells on Cornea Wound Healing Induced by Acute Alkali Burn
    Yao, Lin
    Li, Zhan-rong
    Su, Wen-ru
    Li, Yong-ping
    Lin, Miao-li
    Zhang, Wen-xin
    Liu, Yi
    Wan, Qian
    Liang, Dan
    [J]. PLOS ONE, 2012, 7 (02):
  • [47] Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis
    Cecep Suhandi
    Ahmed Fouad Abdelwahab Mohammed
    Gofarana Wilar
    Ali El-Rayyes
    Nasrul Wathoni
    [J]. Tissue Engineering and Regenerative Medicine, 2023, 20 : 1053 - 1062
  • [48] Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis
    Suhandi, Cecep
    Mohammed, Ahmed Fouad Abdelwahab
    Wilar, Gofarana
    El-Rayyes, Ali
    Wathoni, Nasrul
    [J]. TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023, 20 (07) : 1053 - 1062
  • [49] A pilot study to demonstrate the paracrine effect of equine, adult allogenic mesenchymal stem cells in vitro, with a potential for healing of experimentally-created, equine thoracic wounds in vivo
    Caruso, Michael
    Shuttle, Shannon
    Amelse, Lisa
    Elkhenany, Hoda
    Schumacher, James
    Dhar, Madhu S.
    [J]. FRONTIERS IN VETERINARY SCIENCE, 2022, 9
  • [50] In vitro comparative study of human mesenchymal stromal cells from dermis and adipose tissue for application in skin wound healing
    Zomer, Helena Debiazi
    dos Santos Varela, Gisele Kristina
    Delben, Priscilla Barros
    Heck, Diana
    Jeremias, Talita da Silva
    Trentin, Andrea Goncalves
    [J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2019, 13 (05) : 729 - 741
12345