In vitro study of the mesenchymal stem cells-conditional media role in skin wound healing process: A systematic review

被引：8
作者：
Heydari, Mohammad Bagher [1 ]
Ghanbari-Movahed, Zahra [2 ]
Heydari, Maryam [3 ]
Farzaei, Mohammad Hosein [4 ]
机构：
[1] Kermanshah Univ Med Sci KUMS, Taleghani Hosp, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran
[3] Zabol Univ Med Sci, Dept Pharm, Zabol, Iran
[4] Kermanshah Univ Med Sci, Med Technol Res Ctr, Hlth Technol Inst, Kermanshah 6734667149, Iran
来源：
INTERNATIONAL WOUND JOURNAL | 2022年 / 19卷 / 08期
关键词：
conditional media; mesenchymal stem cells; skin; wound healing; STROMAL CELLS; REGENERATIVE MEDICINE; INFLAMMATORY CELLS; SECRETORY FACTORS; GROWTH-FACTORS; REPAIR; PROLIFERATION; MIGRATION; KERATINOCYTES; MECHANISMS;
D O I：
10.1111/iwj.13796
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mesenchymal stromal cell (MSC)-conditioned medium (CM) offers a potential opportunity in the skin wound healing treatment. In this systematic review, an overview of the knowledge on this topic has been provided. A multistep search of the PubMed, Scopus and Science Direct database has been performed to identify papers on MSCs-conditional media used in skin wound healing. Eligibility checks were performed based upon predefined selection criteria. Of the 485 articles initially identified, consequently, only 96 articles apparently related to MSC-conditional media were initially assessed for eligibility. Finally, the 32 articles, strictly regarding the in vitro use of MSCs-conditional media in skin wounds, were analysed. The information analysed highlights the efficacy of MSCs-conditional media on skin wound healing in vitro models. The outcome of this review may be used to guide pre-clinical and clinical studies on the role of MSCs-conditional media in skin wound healing.
引用
收藏
页码：2210 / 2223
页数：14
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