Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment

被引：10

作者：

Segat, Ludovica ^{[1
,2
,3
]}

Brandao, Lucas A. C. ^{[3
]}

Guimares, Rafael L. ^{[3
]}

Pontillo, Alessandra ^{[1
,2
]}

Athanasakis, Emmanouil ^{[1
,2
]}

de Oliveira, Rafael Martins ^{[4
]}

Arraes, Luiz C. ^{[6
]}

de Lima Filho, Jose Luiz ^{[3
]}

Crovella, Sergio ^{[1
,2
,5
]}

机构：

[1] IRCCS Burlo Garofolo, Genet Serv, I-34137 Trieste, Italy

[2] Univ Trieste, I-34137 Trieste, Italy

[3] Univ Fed Pernambuco, LIKA, Recife, PE, Brazil

[4] Univ Sao Paulo, Lab Invest Med Dermatol & Imunodeficiencias LIM56, BR-05508 Sao Paulo, Brazil

[5] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil

[6] Inst Materno Infantil Prof Fernando Figueira, Recife, PE, Brazil

来源：

VACCINE | 2010年 / 28卷 / 10期

关键词：

Dendritic cell immunotherapy; Innate immunity; HIV infection; MANNOSE-BINDING LECTIN; NITRIC-OXIDE; MONOCYTES; INFECTION; VACCINE; DISEASE; MBL;

D O I：

10.1016/j.vaccine.2009.12.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs)-based vaccine was demonstrated to increase HIV specific cellular immune response; however, in some HIV-infected patients, the response to the vaccine resulted to be not effective. In order to understand if the outcome of the vaccination may be influenced by the host's genome and natural immunity, we studied the innate immune genome of HIV-infected patients previously vaccinated with DCs. We identified 15 SNPs potentially associated with the response to the immuno-treatment and two SNPs significantly associated with the modulation of the response to the DC vaccine: MBL2 rs10824792 and NOS1 rs693534. These two SNPs were also studied in different ethnic groups (Brazilians, African and Caucasian) of HIV-infected, exposed uninfected and unexposed uninfected subjects. The HIV positive Caucasian patients were also characterized by different disease progressions. Our findings suggest that, independently and/or in addition to other variables. the host's genome could significantly contribute to the modulation of the response to the DC vaccine. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2201 / 2206

页数：6

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