A new humanized HLA transgenic mouse model of multiple seleirosis expressing class II on mouse CD4 T cells

被引:8
作者
Mangalam, Ashutosh [1 ]
Rodriguez, Moses [1 ]
David, Chella [1 ]
机构
[1] Mayo Clin, Coll Med, Dept Immunol, Rochester, MN USA
来源
HOW DO WE BEST EMPLOY ANIMAL MODELS FOR TYPE 1 DIABETES AND MULTIPLE SCLEROSIS? | 2007年 / 1103卷
关键词
CD4 T cells; MHC/HLA; MS; transgenic mouse; antigen-presenting cells; PLP; EAE;
D O I
10.1196/annals.1394.005
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Among all the genetic factors associated with susceptibility to multiple sclerosis (MS), the strongest association has been seen with expression of certain major histocompatibility complex (MHC) class II molecules, although analysis of their exact function remains complicated. In general, the expression of class II is restricted to professional antigen-presenting cells; however, human but not mouse CD4+ T cells express class II on their surface. Functional studies of class II+ CD4+ T cells have been hampered due to lack of a proper animal model. Here, we describe development and characterization of a new humanized class II transgenic (tg) mouse expressing HLA-DR3 on mouse endogenous class II-negative background.
引用
收藏
页码:112 / 117
页数:6
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