The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

被引:126
作者
Xu, JC
Koni, PA
Wang, PL
Li, GY
Kaczmarek, L
Wu, YL
Li, YY
Flavell, RA
Desir, GV
机构
[1] Yale Univ, Sch Med, Dept Med, Nephrol Sect, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
[3] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA
[4] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
[5] VA CT Med Ctr, New Haven, CT USA
[6] Med Coll Georgia, Augusta, GA 30912 USA
[7] RIKEN, Res Ctr Allergy & Immunol, Yokohama, Kanagawa, Japan
关键词
D O I
10.1093/hmg/ddg049
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a variety of cellular processes. Kv1.3 channels are expressed in several tissues and believed to participate in cell volume regulation, apoptosis, T cell activation and renal solute homeostasis. Examination of Kv1.3-deficient mice (Kv1.3(-/-)), generated by gene targeting, revealed a previously unrecognized role for Kv1.3 in body weight regulation. Indeed, Kv1.3(-/-) mice weigh significantly less than control littermates. Moreover, knockout mice are protected from diet-induced obesity and gain significantly less weight than littermate controls when placed on a high-fat diet. While food intake did not differ significantly between Kv1.3(-/-) and controls, basal metabolic rate, measured at rest by indirect calorimetry, was significantly higher in knockout animals. These data indicate that Kv1.3 channels may participate in the pathways that regulate body weight and that channel inhibition increases basal metabolic rate.
引用
收藏
页码:551 / 559
页数:9
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