Long noncoding RNAs: lincs between human health and disease

被引：122

作者：

Kwok, Zhi Hao ^{[1
]}

Tay, Yvonne ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Ctr Translat Med, Canc Sci Inst Singapore, Singapore 117599, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2017年 / 45卷

基金：

新加坡国家研究基金会;

关键词：

REPRESSIVE COMPLEX 2; SECONDARY STRUCTURE; ACTIVE CHROMATIN; GENE-EXPRESSION; MESSENGER-RNAS; CELLS REVEALS; X-CHROMOSOME; CANCER; TRANSCRIPTOME; METASTASIS;

D O I：

10.1042/BST20160376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are highly diverse in terms of characteristics and functions. Advances in high-throughput sequencing platforms have enabled the rapid discovery and identification of lncRNAs as key regulatory molecules involved in various cellular processes and their dysregulation in various human diseases. Here, we summarize the current knowledge of the functions and underlying mechanisms of lncRNA activity with a particular focus on cancer biology. We also discuss the potential of lncRNAs as diagnostic and therapeutic targets for clinical applications.

引用

页码：805 / 812

页数：8

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