T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals

被引：19

作者：

Iwai, Leo Kei

Yoshida, Marcia

Sadahiro, Aya

da Silva, Washington Robert

Marin, Maria Lucia

Goldberg, Anna Carla

Juliano, Maria Aparecida

Juliano, Luiz

Shikanai-Yasuda, Maria Aparecida

Kalil, Jorge

Cunha-Neto, Edecio

Travassos, Luiz R.

机构：

[1] Univ Fed Sao Paulo, Disciplina Biol Celular, Dept Microbiol Imunol & Parasitol, BR-04023062 Sao Paulo, Brazil

[2] Millennium Inst, Immunol Lab, Inst Heart, INCOR, Sao Paulo, Brazil

[3] Millennium Inst, Div Clin Immunol & Allergy, Sao Paulo, Brazil

[4] Millennium Inst, Inst Invest Immunol, Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Med, Div Infect & Parasit Dis, Sao Paulo, Brazil

[6] Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo, Brazil

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2007年 / 14卷 / 04期

关键词：

D O I：

10.1128/CVI.00458-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines with synthetic peptides induce the immune response to epitopes that bind to several RLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.

引用

页码：474 / 476

页数：3

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