Asymmetric addition of alkynes to imines in water catalyzed with a recyclable Cu(I)-bis(oxazoline) and stearic acid system

被引：34

作者：

Liu, Juntao

Liu, Bao

Jia, Man

Li, Xingshu ^{[1
]}

Chan, Albert S. C.

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 51006, Peoples R China

[2] Shenyang Pharmaceut Univ, Shenyang, Peoples R China

[3] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetasy.2007.02.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Stearic acid and its zinc salt were used as additives in the enantioselective alkyne addition to imines catalyzed by copper(I)-bis(oxazoline) (box) in water. The reactions took place smoothly with good yields and high enantioselectivities (up to 97% ee). Good enantioselectivities were maintained in a catalyst recycle study. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：396 / 399

页数：4

共 60 条

[1] Three-component enantioselective synthesis of propargylamines through Zr-catalyzed additions of alkyl zinc reagents to alkynylimines [J].