Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis

被引：107
作者：
Broglie, Larisa [1 ,2 ]
Pommert, Lauren [2 ,3 ]
Rao, Sridhar [4 ]
Thakar, Monica [1 ,2 ]
Phelan, Rachel [1 ,2 ]
Margolis, David [1 ,2 ]
Talano, Julie [1 ,2 ]
机构：
[1] Med Coll Wisconsin, Div Hematol Oncol & Blood & Marrow Transplant, Dept Pediat, Milwaukee, WI USA
[2] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
[3] Childrens Hosp Wisconsin, Div Hematol Oncol & Blood & Marrow Transplant, Dept Pediat, Milwaukee, WI 53201 USA
[4] Med Coll Wisconsin, Blood Res Inst, Milwaukee, WI 53226 USA
来源：
BLOOD ADVANCES | 2017年 / 1卷 / 19期
基金：
美国国家卫生研究院;
关键词：
INHIBITOR; TOFACITINIB; BLOCKADE; THERAPY; BIOLOGY; DISEASE;
D O I：
10.1182/bloodadvances.2017007526
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：1533 / 1536
页数：4
相关论文
共 22 条
[1]   Rapid and Sustained Remission of Systemic Juvenile Idiopathic Arthritis-Associated Macrophage Activation Syndrome Through Treatment With Anakinra and Corticosteroids [J].
Bruck, Normi ;
Suttorp, Meinolf ;
Kabus, Maria ;
Heubner, Georg ;
Gahr, Manfred ;
Pessler, Frank .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2011, 17 (01) :23-27
[2]   Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis [J].
Das, Rupali ;
Guan, Peng ;
Sprague, Leslee ;
Verbist, Katherine ;
Tedrick, Paige ;
An, Qi Angel ;
Cheng, Cheng ;
Kurachi, Makoto ;
Levine, Ross ;
Wherry, E. John ;
Canna, Scott W. ;
Behrens, Edward M. ;
Nichols, Kim E. .
BLOOD, 2016, 127 (13) :1666-1675
[3]   Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis [J].
Fleischmann, Roy ;
Kremer, Joel ;
Cush, John ;
Schulze-Koops, Hendrik ;
Connell, Carol A. ;
Bradley, John D. ;
Gruben, David ;
Wallenstein, Gene V. ;
Zwillich, Samuel H. ;
Kanik, Keith S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (06) :495-507
[4]   JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis [J].
Harrison, Claire ;
Kiladjian, Jean-Jacques ;
Al-Ali, Haifa Kathrin ;
Gisslinger, Heinz ;
Waltzman, Roger ;
Stalbovskaya, Viktoriya ;
McQuitty, Mari ;
Hunter, Deborah S. ;
Levy, Richard ;
Knoops, Laurent ;
Cervantes, Francisco ;
Vannucchi, Alessandro M. ;
Barbui, Tiziano ;
Barosi, Giovanni .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (09) :787-798
[5]   HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].
Henter, Jan-Inge ;
Horne, AnnaCarin ;
Arico, Maurizio ;
Egeler, R. Maarten ;
Filipovich, Alexandra H. ;
Imashuku, Shinsaku ;
Ladisch, Stephan ;
McClain, Ken ;
Webb, David ;
Winiarski, Jacek ;
Janka, Gritta .
PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131
[6]   Success with infliximab in treating refractory hemophagocytic lymphohistiocytosis [J].
Henzan, T ;
Nagafuji, K ;
Tsukamoto, H ;
Miyamoto, T ;
Gondo, H ;
Imashuku, S ;
Harada, M .
AMERICAN JOURNAL OF HEMATOLOGY, 2006, 81 (01) :59-61
[7]   Ruxolitinib in a Pediatric Patient with Chronic Gvhd [J].
Karras, Nicole ;
Jung, Jae ;
Cotliar, Jonathan .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (03) :S236-S236
[8]   Biology and significance of the JAK/STAT signalling pathways [J].
Kiu, Hiu ;
Nicholson, Sandra E. .
GROWTH FACTORS, 2012, 30 (02) :88-106
[9]   Salvage therapy for refractory hemophagocytic lymphohistiocytosis: A review of the published experience [J].
Marsh, Rebecca A. ;
Jordan, Michael B. ;
Talano, Julie-An ;
Nichols, Kim E. ;
Kumar, Ashish ;
Naqvi, Ahmed ;
Vaiselbuh, Sarah R. .
PEDIATRIC BLOOD & CANCER, 2017, 64 (04)
[10]   Salvage Therapy of Refractory Hemophagocytic Lymphohistiocytosis With Alemtuzumab [J].
Marsh, Rebecca A. ;
Allen, Carl E. ;
McClain, Kenneth L. ;
Weinstein, Joanna L. ;
Kanter, Julie ;
Skiles, Jodi ;
Lee, Nadine D. ;
Khan, Shakila P. ;
Lawrence, Julia ;
Mo, Jun Q. ;
Bleesing, Jack J. ;
Filipovich, Alexandra H. ;
Jordan, Michael B. .
PEDIATRIC BLOOD & CANCER, 2013, 60 (01) :101-109
123