Analysis of dopamine beta hydroxylase gene polymorphisms in migraine

被引：11
作者：
Sezer, Saime [1 ]
Kurt, Semiha [2 ]
Ates, Omer [1 ]
机构：
[1] Gaziosmanpasa Univ, Dept Med Biol, TR-60100 Tokat, Turkey
[2] Gaziosmanpasa Univ, Fac Med, Dept Neurol, TR-60100 Tokat, Turkey
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2016年 / 145卷
关键词：
Dopamin beta hydroxylase gene; Genetic susceptibility; Migraine; Polymorphism; LINKAGE DISEQUILIBRIUM; DBH LOCUS; ASSOCIATION; SUSCEPTIBILITY;
D O I：
10.1016/j.clineuro.2016.02.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Migraine is a complex neurological disorder characterized by severe recurrent headache, nausea, vomiting, photophobia, and phonophobia. The frequency and duration of these symptoms varies among individuals. Dopaminergic systems are believed to be involved in migraine pathophysiology. We aimed to look for association of polymorphisms in dopaminergic genes in genetic susceptibility to migraine in Turkey population. Methods: The present study was designed to explore possible association of three polymorphisms, (1021C > T (Rs1611115), +1603C > T (Rs6271; C535R) and +444G > A (rs1108580), of Dopamin Beta Hydroxylase gene in migraine patients. 200 migraine patients and 267 healthy controls were included in the study. Genomic DNA was extracted from blood and genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism methods (PCR-RFLP). Results: Statistical evaluation of data results showed a significant association for allelic and genotypic frequency distribution between the Dopamin Beta Hydroxylase gene +1603C > T polymorphism and migraine (p = 0.000, OR: 4.36, 95% CI: 2.73-7.16). There was no association observed between the 1021C > T and +444 G > A polymorphisms of the Dopamin Beta Hydroxylase gene and migraine (p = 0.8731 and p = 0.7584). Conclusions: This study reflects that Dopamin Beta Hydroxylase gene +1603C > T polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：96 / 100
页数：5
相关论文
共 28 条
[21]   DOPAMINE-BETA-HYDROXYLASE IMMUNOREACTIVITY IN HUMAN CEREBROSPINAL-FLUID - PROPERTIES, RELATIONSHIP TO CENTRAL NORADRENERGIC NEURONAL-ACTIVITY AND VARIATION IN PARKINSONS-DISEASE AND CONGENITAL DOPAMINE-BETA-HYDROXYLASE DEFICIENCY [J].
OCONNOR, DT ;
CERVENKA, JH ;
STONE, RA ;
LEVINE, GL ;
PARMER, RJ ;
FRANCOBOURLAND, RE ;
MADRAZO, I ;
LANGLAIS, PJ ;
ROBERTSON, D ;
BIAGGIONI, I .
CLINICAL SCIENCE, 1994, 86 (02) :149-158
[22]   Migraine pathophysiology and its clinical implications [J].
Silberstein, SD .
CEPHALALGIA, 2004, 24 :2-7
[23]   Genotypic and haplotypic associations of the DBH gene with plasma dopamine β-hydroxylase activity in African Americans [J].
Tang, Yi-lang ;
Epstein, Michael P. ;
Anderson, George M. ;
Zabetian, Cyrus P. ;
Cubells, Joseph F. .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2007, 15 (08) :878-883
[24]   Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+1603C→T) with plasma dopamine β-hydroxylase activity [J].
Tang, YL ;
Anderson, GM ;
Zabetian, CP ;
Köhnke, MD ;
Cubells, JF .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 139B (01) :88-90
[25]   New genetic evidence for involvement of the dopamine system in migraine with aura [J].
Todt, Unda ;
Netzer, Christian ;
Toliat, Mohammad ;
Heinze, Axel ;
Goebel, Ingrid ;
Nuernberg, Peter ;
Goeel, Hartmut ;
Freudenberg, Jan ;
Kubisch, Christian .
HUMAN GENETICS, 2009, 125 (03) :265-279
[26]   Dopamine Beta-Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study [J].
Yamamoto, K ;
Cubells, JF ;
Gelernter, J ;
Benkelfat, C ;
Lalonde, P ;
Bloom, D ;
Lal, S ;
Labelle, A ;
Turecki, G ;
Rouleau, GA ;
Joober, R .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 117B (01) :33-38
[27]   The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine β-hydroxylase activity [J].
Zabetian, CP ;
Buxbaum, SG ;
Elston, RC ;
Köhnke, MD ;
Anderson, GM ;
Gelernter, J ;
Cubells, JF .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (06) :1389-1400
[28]   A quantitative-trait analysis of human plasma-dopamine β-hydroxylase activity:: Evidence for a major functional polymorphism at the DBH locus [J].
Zabetian, CP ;
Anderson, GM ;
Buxbaum, SG ;
Elston, RC ;
Ichinose, H ;
Nagatsu, T ;
Kim, KS ;
Kim, CH ;
Malison, RT ;
Gelernter, J ;
Cubells, JF .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (02) :515-522
123