Heavy metals pollution is an important challenge that was cussed by human activity, this stress decreases under salinity. The aim of this study was to investigate the ability of Japanese raisin in the absorption of nitrate (0, 30, and 60 mgL-1) and lead (0, 300, and 600 mgL-1) under salinity stress (0 as control and 3 and 6 dSm1). Results showed that the studied plant continued to uptake nitrate and potassium under stress conditions of Pb and salinity. Although Na and Cl uptake were observed as a defense mechanism in the plant, the K/Na ratio, and K content increased from 1 to 6 and from 1.8 to 5%, respectively. Also, the most appropriate physiological responses were observed at treatments under contamination level of 300 mg Pb and salinity level of 3 dSm1, so that the synthesis of malondialdehyde (MDA) and enzymatic activity increased at these levels of HMs and salinity. Based on the results, the studied species were able to uptake moderate concentrations of Pb (34.1-71mg kg-1) under experimen-tal conditions. Hence, its potential for the clean-up of some contaminants in the envi-ronment can be considered by researchers for further research.Novelty statement. This study investigated the cleaning up of some heavy metals and nitrate from the environment and plants' physiological responses under stressful condi-tions. The plant species (Japanese raisin) characteristics and the results have enough novelty and will be published for the first time. Most hardwood trees such as walnut, oak, beech, poplar, etc. have a slow growth rate. But Japanese raisin tree a new and unknown plant in Iran has very important features. This tree is one of the few trees that in addition to having hardwood, has a very high growth rate. Which can be useful in creating artificial forests, Landscapes, as well as in industrial applications, buildings, and furniture industries. So far, no special research has been done on the phytoreme-diation characteristics of this plant and the selection of this plant in the present study and the study of the ability of this plant to absorb nitrate and lead under salinity stress is a completely new and innovative topic.