PET/CT of Dementia

被引：22

作者：

Zukotynski, Katherine ^{[1
,2
,3
]}

Kuo, Phillip H. ^{[4
,5
,6
]}

Mikulis, David ^{[7
]}

Rosa-Neto, Pedro ^{[8
]}

Strafella, Antonio P. ^{[9
,10
,11
]}

Subramaniam, Rathan M. ^{[12
]}

Black, Sandra E. ^{[13
,14
]}

机构：

[1] McMaster Univ, Dept Med, 1200 Main St W,Rm 1P11, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Radiol, Hamilton, ON, Canada

[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

[4] Univ Arizona, Dept Med Imaging, Tucson, AZ USA

[5] Univ Arizona, Dept Med, Tucson, AZ USA

[6] Univ Arizona, Dept Biomed Engn, Tucson, AZ USA

[7] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[8] McGill Univ, Montreal Neurol Inst, Douglas Res Ctr, Montreal, PQ, Canada

[9] Univ Hlth Network, Toronto Western Hosp, Neurol Div, Dept Med, Toronto, ON, Canada

[10] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada

[11] Campbell Family Mental Hlth Res Inst, Res Imaging Ctr, Toronto, ON, Canada

[12] UT Southwestern Med Ctr, Dept Radiol, Dallas, TX USA

[13] Univ Toronto, Neurol Div, Dept Med, Toronto, ON, Canada

[14] Sunnybrook Res Inst, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF ROENTGENOLOGY | 2018年 / 211卷 / 02期

关键词：

amyloid; dementia; imaging; PET/CT; tau; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA PLAQUES; ALZHEIMERS-DISEASE; FDG-PET; NEUROFIBRILLARY PATHOLOGY; ANATOMIC STANDARDIZATION; TRANSLOCATOR PROTEIN; AMERICAN-ACADEMY; IMAGING AGENT;

D O I：

10.2214/AJR.18.19822

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

引用

页码：246 / 259

页数：14

共 97 条

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