Two new ditetrahydrofuran lignans from Artemisia sieversiana

被引：11

作者：

Zhou, Xu-Dong ^{[1
,2
]}

Xu, Xiang-Wei ^{[3
]}

Shi, Lun-Yong ^{[1
]}

Chen, Sheng-Huang ^{[2
]}

Zeng, Ke-Wu ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China

[2] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha, Hunan, Peoples R China

[3] Yongkang First Peoples Hosp, Pharm Dept, Yongkang, Zhejiang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Asteraceae; Artemisia sieversiana; lignans; sieverlignan; anti-neuroinflammatory; STEREOCHEMISTRY; DERIVATIVES; FLAVONOIDS; TERPENOIDS;

D O I：

10.1080/14786419.2020.1712384

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the compounds were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compound 2 exhibited the significant activity with its IC50 value of 11.9 +/- 0.8 mu M, respectively, compared to a positive control quercetin with its IC50 value of 16.0 +/- 1.1 mu M.

引用

页码：3528 / 3534

页数：7

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