Bimorpholines as alternative organocatalysts in asymmetric aldol reactions

被引：1
|
作者：
Kriis, Kadri [1 ]
Laars, Marju [1 ]
Lippur, Kristin [1 ]
Kanger, Tonis [1 ]
机构：
[1] Tallinn Univ Technol, Dept Chem, EE-12618 Tallinn, Estonia
来源：
CHIMIA | 2007年 / 61卷 / 05期
关键词：
aldol condensation; bimorpholine; organocatalysis; stereoselective;
D O I：
10.2533/chimia.2007.232
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Asymmetric organocatalytic aldol condensation is discussed on the basis of intramolecular and intermolecular reactions. In addition to the widely used proline and its derivatives an application of the new type of the organocatalyst - bimorpholines in the above-mentioned reactions is described. The new catalyst has a unique C-2-symmetric skeleton with four acceptor sites that makes it stereoselective and efficient. Small changes in the structure of the catalyst lead to a remarkable loss of selectivity.
引用
收藏
页码：232 / 235
页数：4
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