Effect of Zn and Ga doping on bioactivity, degradation, and antibacterial properties of borate 1393-B3 bioactive glass

被引：44

作者：

Mutlu, Nurshen ^{[1
,2
]}

Kurtuldu, Fatih ^{[1
,2
]}

Unalan, Irem ^{[2
]}

Nescakova, Zuzana ^{[1
]}

Kankova, Hana ^{[1
]}

Galuskova, Dagmar ^{[1
]}

Michalek, Martin ^{[1
]}

Liverani, Liliana ^{[2
]}

Galusek, Dusan ^{[1
,3
]}

Boccaccini, Aldo R. ^{[2
]}

机构：

[1] Alexander Dubcek Univ Trencin, Ctr Funct & Functionalized Glass, FunGlass, Trencin 91150, Slovakia

[2] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany

[3] TnU AD, Joint Glass Ctr IIC SAS TnU AD & FChFT STU, Ctr Funct & Surface Functionalized Glass, Trencin, Slovakia

来源：

CERAMICS INTERNATIONAL | 2022年 / 48卷 / 11期

关键词：

Bioactive glasses; Borate glasses; Zinc; Gallium; Antibacterial activity; IN-VITRO; OXIDE ADDITION; ZINC; GALLIUM; BORON; BONE; SCAFFOLDS; BOROSILICATE; SILICATE; EFFICACY;

D O I：

10.1016/j.ceramint.2022.02.192

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Borate 1393-B3 bioactive glasses doped with ZnO or Ga2O3 (1, 3, and 6% mol) were produced by conventional melt quenching. All doped glasses showed in-vitro bioactivity in simulated body fluid (SBF). For the first time, the dissolution behavior of the glasses both in phosphate-buffered saline (PBS) and cell culture medium was investigated. The ion release rate in the cell culture medium increased compared to that in PBS solution. All tested glass compositions, including the parent 1393-B3 glass, showed antibacterial effect against S. aureus and E. coli. The incorporation of Zn and Ga enhanced the viability of MG-63 osteoblast-like cells compared to the base 1393-B3 glass. The results show the potential of Zn and Ga-doped borate glasses in multifunctional tissue engineering applications.

引用

页码：16404 / 16417

页数：14

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