Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release

被引：10

作者：

Young, AH

Rue, J

Odontiadis, J

Cowen, PJ

机构：

[1] Univ Newcastle Upon Tyne, Royal Victoria Infirm, Sch Neurosci, Div Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Univ Oxford, Littlemore Hosp, Dept Psychiat, Oxford OX4 4XN, England

来源：

PSYCHOPHARMACOLOGY | 1998年 / 136卷 / 02期

基金：

英国惠康基金;

关键词：

serotonin; d-fenfluramine; prolactin; hydrocortisone; neuroendocrine; depression;

D O I：

10.1007/s002130050556

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prolactin responses to the serotonin (5-HT) releasing agent d-fenfluramine (30 mg orally) were studied in 11 male normal volunteers after administration of hydrocortisone (20 mg orally, twice daily for 10 days) using a double-blind, placebo-controlled, cross-over design. While hydrocortisone treatment significantly elevated 24-h urinary cortisol excretion, it did not lower the prolactin response to d-fenfluramine. Plasma levels of d-fenfluramine and d-norfenfluramine were not altered by hydrocortisone treatment. These findings show that following 10 days administration of hydrocortisone, the prolactin responses to d-fenfluramine are not changed.

引用

页码：198 / 200

页数：3

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