Diagnostic and prognostic classification of atypical spitzoid tumours based on histology and genomic aberrations: A prospective cohort study with long-term follow-up

被引:5
作者
Gassenmaier, Maximilian [1 ]
Soltanpour, Narges [1 ]
Held, Laura [1 ,2 ]
Metzler, Gisela [1 ,3 ]
Yazdi, Amir S. [1 ,4 ]
Brecht, Ines B. [5 ]
Schneider, Dominik T. [6 ]
Stadler, Rudolf [7 ]
Garbe, Claus [1 ,8 ]
Bauer, Juergen [1 ,8 ]
机构
[1] Eberhard Karls Univ Tubingen, Dept Dermatol, Tubingen, Germany
[2] MVZ Dermatopathol Friedrichshafen Bodensee PartG, Siemensstr 6-1, D-88048 Friedrichshafen, Germany
[3] Zentrum Dermatohistol & Oralpathol Tubingen, Tubingen, Germany
[4] Univ Hosp RWTH Aachen, Dept Dermatol & Allergol, Aachen, Germany
[5] Eberhard Karls Univ Tubingen, Childrens Hosp, Pediat Hematol & Oncol, Tubingen, Germany
[6] Dortmund Municipal Hosp, Clin Pediat, Dortmund, Germany
[7] Ruhr Univ Bochum, Johannes Wesling Med Ctr, Univ Hosp, Dept Dermatol Venereol Allergol & Phlebol, Minden, Germany
[8] Dermatol Stuttgart, Stuttgart, Germany
关键词
Array comparative genomic hybridisation; Atypical spitz tumour; Histology; Melanoma; Prognosis; Sentinel lymph node biopsy; MELANOCYTIC TUMORS; DIFFERENTIAL-DIAGNOSIS; MELANOMA; NEVI; HYBRIDIZATION; NEOPLASMS; OUTCOMES; EXPRESSION; MUTATIONS; INVASION;
D O I
10.1016/j.ejca.2021.12.016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Histological classification of atypical spitzoid tumours (ASTs) is un-reliable, and categorisation of these lesions into benign and malignant is poorly reproducible. Here, we classified ASTs based on histology and chromosomal aberrations and explored the prognostic significance of genomic aberrations in a prospective cohort with a long-term follow-up.Patients and methods: Histologically equivocal ASTs from 76 patients were analysed by array comparative genomic hybridisation (aCGH). Tumours were histologically assessed by a panel of dermatopathologist before and after aCGH and classified as benign, ambiguous or malig-nant. Chromosomal aberrations were correlated with an outcome. Results: Chromosomal aberrations were detected in 45 (59%) of 76 ASTs (median age: 16 years, range: 0-74; median follow-up: 90 months, range: 13-153). The initial histological diagnosis was changed upon presentation of aCGH results in 36 of 76 cases (47%). The final diagnostic interpretation classified 61% of the lesions as benign, 18% as ambiguous and 21% as malignant. Positive sentinel lymph node biopsies (6 thorn /29) occurred at similar rates in all diag-nostic groups (P Z 0.83) and were not associated with an unfavourable outcome. Two pa-tients had local recurrences, but none of the patients developed metastasis beyond the sentinel lymph node.Conclusions: All ASTs had an excellent prognosis, even in cases with worrisome morphology and chromosomal aberrations. With no distant metastasis or death in long-term follow-up of 76 patients, no correlation between chromosomal aberrations and prognosis was possible. However, it seems likely that in larger cohorts, metastases would arise in cases with complex aberrations and these patients should undergo clinical follow-up.(c) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页码:200 / 210
页数:11
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