(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines

被引：59

作者：

Zhang, Shang-Shi ^{[1
]}

Liu, Xu-Ge ^{[1
]}

Chen, Shi-Yong ^{[1
]}

Tan, Dong-Hang ^{[1
]}

Jiang, Chun-Yong ^{[1
]}

Wu, Jia-Qiang ^{[1
]}

Li, Qingjiang ^{[1
]}

Wang, Honggen ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 10期

基金：

中国国家自然科学基金;

关键词：

annulation; cerium salts; C-H activation; cobalt; isoquinolines; CARBON-CARBON BONDS; C-H; INTERNAL ALKYNES; COBALT(III)-CATALYZED ARYL; DIRECT FUNCTIONALIZATION; BETA-PHENYLETHYLAMINES; ASYMMETRIC CATALYSIS; IRIDIUM COMPLEXES; MILD CONDITIONS; ACTIVATION;

D O I：

10.1002/adsc.201600025

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A synthetic method for isoquinoline synthesis via a [4+2] annulation of N-H imines with alkynes using the high-valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed.

引用

页码：1705 / 1710

页数：6

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