The Hyperfiltering Kidney in Diabetes

被引：23
作者：
Trevisan, Roberto [1 ]
Dodesini, Alessandro Roberto [1 ]
机构：
[1] ASST Papa Giovanni XXIII, USC Malattie Endocrine Diabetol, IT-24100 Bergamo, Italy
来源：
NEPHRON | 2017年 / 136卷 / 04期
关键词：
Hyperfiltration; Diabetes; Intraglomerular pressure; Diabetic nephropathy; GLOMERULAR HYPERFILTRATION; RENAL HYPERFILTRATION; PROGRESSION; DISEASE; EMPAGLIFLOZIN; INHIBITION; MELLITUS; SIZE;
D O I：
10.1159/000448183
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes. (C) 2016 S. Karger AG, Basel
引用
收藏
页码：277 / 280
页数：4
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