Synthesis, crystal structure, and biological activity of a nickel(II) complex of 2-acetylpyridine N(4)-methylthiosemicarbazone

被引：12

作者：

Chen, Dan-Yun ^{[1
]}

Chen, Chun-Ling ^{[1
]}

Li, Ming-Xue ^{[1
]}

Niu, Jing-Yang ^{[1
]}

Zhu, Xian-Feng ^{[2
,3
]}

Guo, Hong-Mei ^{[2
,3
]}

机构：

[1] Henan Univ, Coll Chem & Chem Engn, Inst Mol & Crystal Engn, Kaifeng 475004, Peoples R China

[2] Henan Univ, Bioengn Inst, Kaifeng 475001, Peoples R China

[3] Henan Univ, Coll Life Sci, Kaifeng 475001, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 09期

基金：

中国博士后科学基金;

关键词：

Thiosemicarbazone complex; Crystal structure; Cytotoxic activity; COPPER(II) COMPLEXES; ANTIBACTERIAL ACTIVITY; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; SPECTRAL CHARACTERIZATION; PALLADIUM(II) COMPLEXES; IRON(III) COMPLEXES; METAL-COMPLEXES; ANTITUMOR; CHEMISTRY;

D O I：

10.1080/00958972.2010.484490

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nickel complex formulated as Ni(L)2 (L = monodeprotonated ligand corresponding to 2-acetylpyridine N(4)-methylthiosemicarbazone, HL) has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The complex consists of discrete monomeric molecules with octahedral nickel(II) with two anionic 2-acetylpyridine N(4)-methylthiosemicarbazones as NNS tridentate ligands coordinated to nickel via the pyridine nitrogen, azomethine nitrogen, and sulfur. Hydrogen bonds link the different components to stabilize the crystal structure. Biological studies, carried out in vitro against bacteria, fungi, and the K562 leukemic cell line have shown that the free ligand and complex show distinct differences in biological activity.

引用

页码：1546 / 1554

页数：9

共 35 条

[1] Synthesis and characterization of indium(III) complexes with tri- and pentadentate thiosemicarbazones. Crystal and molecular structure of [InCl2(HDAPTSC)]center dot 2DMSO, {O[In(HDAPTSC)(OH)](2))center dot 5MeOH, [InCl2-(APTSC)(MeOH)], [In(APTSC)(2)]PF6 and (H(2)APTSC)][InCl(APTSC)(mnt)]center dot 0.5H(2)O (H(2)DAPTSC equals 2,6-diacetylpyridine-bis(thiosemicarbazone), HAPTSC equals 2-acetylpyridine-thiosemicarbazone, mnt(2-) equals 1,2-dicyanoethene-1,2-dithiolate) [J].

Abram, S ;

MaichleMossmer, C ;

Abram, U .

POLYHEDRON, 1998, 17 (01) :131-143

[2]

ALI MA, 1974, COORDIN CHEM REV, V13, P101

[3] The wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes [J].

Beraldo, H ;

Gambino, D .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2004, 4 (01) :31-39

[4]

Bermejo E, 1999, EUR J INORG CHEM, P965

[5] Metal complexes of 2-benzoylpyridine-derived thiosemicarbazones:: structural, electrochemical and biological studies [J].

Costa, RFF ;

Rebolledo, AP ;

Matencio, T ;

Calado, HDR ;

Ardisson, JD ;

Cortés, ME ;

Rodrigues, BL ;

Beraldo, H .

JOURNAL OF COORDINATION CHEMISTRY, 2005, 58 (15) :1307-1319

[6] Iron(III) complexes with N4-para-tolyl-thiosemicarbazones: spectral and electrochemical studies and toxicity to Artemia salina [J].

Dos Santos Silva, Thays ;

Teixeira, Leticia R. ;

Ziolli, Roberta L. ;

Louro, Sonia R. W. ;

Beraldo, Heloisa .

JOURNAL OF COORDINATION CHEMISTRY, 2009, 62 (06) :958-966

[7] Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain [J].

Du, XH ;

Guo, C ;

Hansell, E ;

Doyle, PS ;

Caffrey, CR ;

Holler, TP ;

McKerrow, JH ;

Cohen, FE .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (13) :2695-2707

[8] Biomedical uses and applications of inorganic chemistry. An overview [J].

Farrell, N .

COORDINATION CHEMISTRY REVIEWS, 2002, 232 (1-2) :1-4

[9] Synthesis and spectroscopic properties of copper(II) complexes derived from thiophene-2-carbaldehyde thiosemicarbazone.: Structure and biological activity of [Cu(C6H6N3S2)2] [J].

García-Tojal, J ;

Garcia-Orad, A ;

Serra, JL ;

Pizarro, JL ;

Lezama, L ;

Arriortua, MI ;

Rojo, T .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 75 (01) :45-54

[10] The preparation, characterization, crystal structure and biological activities of some copper(II) complexes of the 2-benzoylpyridine Schiff bases of S-methyl- and S-benzyldithiocarbazate [J].

Hossain, ME ;

Alam, MN ;

Begum, J ;

Ali, MA ;

Nazimuddin, M ;

Smith, FE ;

Hynes, RC .

INORGANICA CHIMICA ACTA, 1996, 249 (02) :207-213

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