Controlling degradation of hydrogels via the size of cross-linked junctions

被引：95

作者：

Kong, HJ

Alsberg, E

Kaigler, D

Lee, KY

Mooney, DJ ^{[1
]}

机构：

[1] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol & Mat Sci Dent, Ann Arbor, MI 48109 USA

[4] Hanyang Univ, Coll Chem Engn, Seoul 133791, South Korea

来源：

ADVANCED MATERIALS | 2004年 / 16卷 / 21期

关键词：

D O I：

10.1002/adma.200400014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The degradation rates of hydrogels are shown to be regulated by the modulation of the dissociation rates of the polymer chains via a size mismatch in the crosslinking zones. This method (used to control degradation) can be exploited in order to engineer cartilage tissue in vivo (see Figure).

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页码：1917 / +

页数：6

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