Oxidant-Triggered C1-Benzylation of Isoquinoline by Iodine-Catalyzed Cross-Dehydrogenative-Coupling with Methylarenes

被引：16

作者：

Shi, Xin ^{[1
]}

Zhang, Feng ^{[2
]}

Luo, Wen-Kun ^{[1
]}

Yang, Luo ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Hunan, Peoples R China

[2] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China

来源：

SYNLETT | 2017年 / 28卷 / 04期

关键词：

benzylation; Minisci reaction; iodine; isoquinoline; isoquinolinone; AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; C-H; MINISCI REACTION; ALKYLATION; HETEROCYCLES; ALKALOIDS; ALDEHYDES; ETHERS; ALKANES;

D O I：

10.1055/s-0036-1588331

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical iodine-catalyzed oxidative functionalization of isoquinolines with methylarenes is developed, which can be triggered by the selected oxidants to produce C-1- or N-benzyl-substituted products selectively. This method utilizes readily available isoquinolines and methylarenes as starting materials and proceeds under metal-free conditions with broad substrate scope with respect to methylarenes, avoiding the usage of expensive metal catalysts and generation of halide and metal wastes.

引用

页码：494 / 498

页数：5

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