A review of cardiovascular toxicity of TiO2, ZnO and Ag nanoparticles (NPs)

被引：54
作者：
Cao, Yi [1 ,2 ]
Gong, Yu [1 ]
Liao, Wenzhen [2 ]
Luo, Yunfeng [1 ]
Wu, Chaohua [1 ]
Wang, Maolin [1 ]
Yang, Qianyu [1 ]
机构：
[1] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Lab Biochem, Xiangtan 411105, Peoples R China
[2] Southern Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangdong Prov Key Lab Trop Dis Res, 1023 S Shatai Rd, Guangzhou 510515, Guangdong, Peoples R China
来源：
BIOMETALS | 2018年 / 31卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Nanoparticles (NPs); Bio-distribution; Cardiovascular toxicity; Oxidative stress; Inflammation; ZINC-OXIDE NANOPARTICLES; TITANIUM-DIOXIDE NANOPARTICLES; ENDOPLASMIC-RETICULUM STRESS; WALLED CARBON NANOTUBES; SILVER NANOPARTICLES; IN-VITRO; ENDOTHELIAL-CELLS; PULMONARY EXPOSURE; OXIDATIVE STRESS; VASCULAR TOXICITY;
D O I：
10.1007/s10534-018-0113-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To ensure the safe use of nanoparticles (NPs) in modern society, it is necessary and urgent to assess the potential toxicity of NPs. Cardiovascular system is required for the systemic distribution of NPs entering circulation. Therefore, the adverse cardiovascular effects of NPs have gained extensive research interests. Metal based NPs, such as TiO2, ZnO and Ag NPs, are among the most popular NPs found in commercially available products. They may also have potential applications in biomedicine, which could increase their contact with cardiovascular systems. This review aimed at providing an overview about the adverse cardiovascular effects of TiO2, ZnO and Ag NPs. We discussed about the bio-distribution of NPs following different exposure routes. We also discussed about the cardiovascular toxicity of TiO2, ZnO and Ag NPs as assessed by in vivo and in vitro models. The possible mechanisms and contribution of physicochemical properties of metal based NPs were also discussed.
引用
收藏
页码：457 / 476
页数：20
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