Osteopontin Levels in Human Milk Vary Across Countries and Within Lactation Period: Data From a Multicenter Study

被引:50
作者
Bruun, Signe [1 ,2 ,3 ,4 ]
Jacobsen, Lotte Neergaard [1 ]
Ze, Xiaolei [5 ]
Husby, Steffen [2 ,3 ,4 ]
Ueno, Hiroshi M. [6 ]
Nojiri, Keisuke [6 ]
Kobayashi, Shunjiro [6 ]
Kwon, Jungil [7 ]
Liu, Xihong [8 ]
Yan, Shuyuan [9 ]
Yang, Jiyeon [7 ]
Zachariassen, Gitte [2 ,3 ,4 ]
Chen, Liang [5 ]
Zhou, Wei [10 ]
Christensen, Brian [11 ]
Sorensen, Esben S. [11 ]
机构
[1] Arta Foods Ingredients Grp PS, Strateg Business Unit Pediat, Viby J, Denmark
[2] Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, Odense, Denmark
[3] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark
[4] Odense Univ Hosp, Odense Patient Data Explorat Network, OPEN, Odense, Denmark
[5] Biostime Guangzhou Hlth Prod Ltd, Hlth Sci Dept, Guangzhou, Guangdong, Peoples R China
[6] Bean Stalk Snow Co Ltd, Res & Dev Dept, Kawagoe, Saitama, Japan
[7] Maeil Dairies Co Ltd, Maeil Innovat Ctr, Human Milk Res & Dev Dept, Gyeonggi, South Korea
[8] Guangzhou Women & Childrens Med Ctr, Dept Clin Nutr, Guangzhou, Guangdong, Peoples R China
[9] Changsha Hosp Maternal & Child Hlth Care, Child Hlth Care Ctr, Changsha, Hunan, Peoples R China
[10] Guangzhou Women & Childrens Med Ctr, Dept Neonatol, Guangzhou, Guangdong, Peoples R China
[11] Aarhus Univ, Dept Mol Biol & Genet, Gustav Wieds Vej 10, DK-8000 Aarhus C, Denmark
关键词
bioactive milk protein; breast milk; milk composition; observational study; BOVINE OSTEOPONTIN; BREAST-MILK; FORMULA; MOTHERS; PHOSPHORYLATION; IDENTIFICATION; PROFILES; RECEPTOR; INFANTS; PEPTIDE;
D O I
10.1097/MPG.0000000000002004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: Osteopontin (OPN) is a multifunctional protein expressed in many cell types, tissues and body fluids with the highest concentrations found in milk; significantly higher in human than in bovine milk. intervention studies have indicated beneficial effects of supplementing infant formula with bovine OPN. In this multicenter study, we determined the OPN content in human milk samples from 629 Chinese, Danish, Japanese and Korean mothers. Methods: At each study site, milk samples were collected and analyzed for OPN and protein concentration using ELISA and infrared spectroscopy, respectively. Results: A total of 829 milk samples from 629 women were included. When delivering the first sample, mean maternal age was 31.4 years (SD 4.0), and median infant age was 13.4 weeks (interquartile range 4.6-17.9). The median OPN concentration varied across sites; from 99.7 mg/L in Danish. 185.0 mg/L in Japanese, 216.2 mg/L in Korean to 266.2 mg/L in Chinese mothers (P < 0.001), corresponding to 1.3%, 2.4%, 1.8% and 2.7% of the total protein content (OPN/protein%) (P < 0.05), respectively. Based on 75 Chinese and 33 Japanese mothers delivering more than 1 sample, multilevel (mixed model) linear regression analysis showed a decrease in OPN concentration with infant age (beta=(-11.3), 95% confidence interval (CI) = (-13.9) to (-8.8) and beta= (-2.1), 95% CI = (-3.2) to (-0.9), respectively). Conclusions: In this large multicenter study, we observed statistically significant differences in the OPN concentration and the OPN/protein% in human milk samples between countries. Based on mothers delivering more than I sample, a significant decrease within the lactation period was observed.
引用
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页码:250 / 256
页数:7
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