A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments

被引：80
作者：
Sharma, Ganesh N. [1 ]
Gupta, Gaurav [1 ]
Sharma, Piyush [2 ]
机构：
[1] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur 302017, Raj, India
[2] Maharishi Arvind Coll Pharm, Jaipur 302023, Raj, India
来源：
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2018年 / 28卷 / 02期
关键词：
free radicals; antioxidants; reactive oxygen species; reactive nitrogen species; ALPHA-LIPOIC ACID; OXIDATIVE STRESS; GASTRIC-LESIONS; IN-VIVO; MITOCHONDRIAL; BIOLOGY; DAMAGE; POLYSACCHARIDES; INFLAMMATION; ACTIVATION;
D O I：
10.1615/CritRevEukaryotGeneExpr.2018022258
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The role of free radicals in various human ailments is well established. Still, the researchers continue to emphasize the involvement of free radicals in these disorders. Antioxidants are being used as an effective tool as a defense against disorders caused by free radicals. This review presents brief detail regarding the nature, types, and sources of free radicals that are of pharmacological interest. A summary of the antioxidants, along with possible mechanisms, has also been incorporated. The role of free radicals and antioxidants in various human disease are also presented.
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页码：139 / 154
页数：16
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