A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments

被引:80
作者
Sharma, Ganesh N. [1 ]
Gupta, Gaurav [1 ]
Sharma, Piyush [2 ]
机构
[1] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur 302017, Raj, India
[2] Maharishi Arvind Coll Pharm, Jaipur 302023, Raj, India
来源
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2018年 / 28卷 / 02期
关键词
free radicals; antioxidants; reactive oxygen species; reactive nitrogen species; ALPHA-LIPOIC ACID; OXIDATIVE STRESS; GASTRIC-LESIONS; IN-VIVO; MITOCHONDRIAL; BIOLOGY; DAMAGE; POLYSACCHARIDES; INFLAMMATION; ACTIVATION;
D O I
10.1615/CritRevEukaryotGeneExpr.2018022258
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The role of free radicals in various human ailments is well established. Still, the researchers continue to emphasize the involvement of free radicals in these disorders. Antioxidants are being used as an effective tool as a defense against disorders caused by free radicals. This review presents brief detail regarding the nature, types, and sources of free radicals that are of pharmacological interest. A summary of the antioxidants, along with possible mechanisms, has also been incorporated. The role of free radicals and antioxidants in various human disease are also presented.
引用
收藏
页码:139 / 154
页数:16
相关论文
共 99 条
  • [1] Physiological and pathophysiological reactive oxygen species as probed by EPR spectroscopy: the underutilized research window on muscle ageing
    Abdel-Rahman, Engy A.
    Mahmoud, Ali M.
    Khalifa, Abdulrahman M.
    Ali, Sameh S.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (16): : 4591 - 4613
  • [2] Mitochondrial and Chromosomal Damage Induced by Oxidative Stress in Zn2+ Ions, ZnO-Bulk and ZnO-NPs treated Allium cepa roots
    Ahmed, Bilal
    Dwivedi, Sourabh
    Abdin, Malik Zainul
    Azam, Ameer
    Al-Shaeri, Majed
    Khan, Mohammad Saghir
    Saquib, Quaiser
    Al-Khedhairy, Abdulaziz A.
    Musarrat, Javed
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [3] Pyridoxamine: An extremely potent scavenger of 1,4-dicarbonyls
    Amarnath, V
    Amarnath, K
    Amarnath, K
    Davies, S
    Roberts, LJ
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (03) : 410 - 415
  • [4] Optimization of metabolic capacity and flux through environmental cues to maximize hydrogen production by the cyanobacterium "Arthrospira (Spirulina) maxima"
    Ananyev, Gennady
    Carrieri, Damian
    Dismukes, G. Charles
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (19) : 6102 - 6113
  • [5] Functional Oxygen Sensitivity of Astrocytes
    Angelova, Plamena R.
    Kasymov, Vitaliy
    Christie, Isabel
    Sheikhbahaei, Shahriar
    Turovsky, Egor
    Marina, Nephtali
    Korsak, Alla
    Zwicker, Jennifer
    Teschemacher, Anja G.
    Ackland, Gareth L.
    Funk, Gregory D.
    Kasparov, Sergey
    Abramov, Andrey Y.
    Gourine, Alexander V.
    [J]. JOURNAL OF NEUROSCIENCE, 2015, 35 (29) : 10460 - 10473
  • [6] [Anonymous], 2012, AM J CRIT CARE
  • [7] Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical
    Bandyopadhyay, D
    Biswas, K
    Bandyopadhyay, U
    Reiter, RJ
    Banerjee, RK
    [J]. JOURNAL OF PINEAL RESEARCH, 2000, 29 (03) : 143 - 151
  • [8] Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance in Saccharomyces cerevisiae
    Bankapalli, Kondalarao
    Saladi, SreeDivya
    Awadia, Sahezeel S.
    Goswami, Arvind Vittal
    Samaddar, Madhuja
    D'Silva, Patrick
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (44) : 26491 - 26507
  • [9] INVOLVEMENT OF REACTIVE OXYGEN SPECIES IN KIDNEY DAMAGE
    BAUD, L
    ARDAILLOU, R
    [J]. BRITISH MEDICAL BULLETIN, 1993, 49 (03) : 621 - 629
  • [10] Oxidative Stress and Antioxidant Defense
    Birben, Esra
    Sahiner, Umit Murat
    Sackesen, Cansin
    Erzurum, Serpil
    Kalayci, Omer
    [J]. WORLD ALLERGY ORGANIZATION JOURNAL, 2012, 5 : 9 - 19