Hereditary Kidney Cancer Syndromes and Surgical Management of the Small Renal Mass

被引：4

作者：

Nguyen, Kevin A. ^{[1
]}

Syed, Jamil S. ^{[1
]}

Shuch, Brian ^{[2
,3
]}

机构：

[1] Yale Sch Med, Dept Urol, 789 Howard Ave, New Haven, CT 06520 USA

[2] Yale Sch Med, Dept Radiol, POB 208058, New Haven, CT 06520 USA

[3] Yale Sch Med, Dept Urol, POB 208058, New Haven, CT 06520 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2017年 / 44卷 / 02期

关键词：

Hereditary syndrome; Nephron-sparing surgery; Renal cell carcinoma; Multifocal kidney cancer; Germline alterations; TUBEROUS SCLEROSIS COMPLEX; NEPHRON-SPARING SURGERY; FUMARATE-HYDRATASE GENE; TYROSINE KINASE DOMAIN; LYMPH-NODE DISSECTION; CELL CARCINOMA; RADICAL NEPHRECTOMY; SUCCINATE-DEHYDROGENASE; GERMLINE MUTATIONS; COWDEN-DISEASE;

D O I：

10.1016/j.ucl.2016.12.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The management of patients with hereditary kidney cancers presents unique challenges to clinicians. In addition to an. earlier age of onset compared with patients with sporadic kidney cancer, those with hereditary kidney cancer syndromes often present with bilateral and/or multifocal renal tumors and are at risk for multiple de novo lesions. This population of patients may also present with extrarenal manifestations, which adds an additional layer of complexity. Physicians who manage these patients should be familiar with the underlying clinical characteristics of each hereditary kidney cancer syndrome and the suggested surgical approaches and recommendations of genetic testing for at-risk individuals.

引用

页码：155 / +

页数：14

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