Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients

被引：15
作者：
Costa, P [1 ]
Rusconi, S
Fogli, M
Mavilio, D
Murdaca, G
Puppo, F
Mingari, MC
Galli, M
Moretta, L
De Maria, A
机构：
[1] Univ Genoa, Dipartimento Med Interna, Genoa, Italy
[2] Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy
[3] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy
[4] Univ Milan, Ist Malattie Infett & Trop, Milan, Italy
[5] Ist Sci G Gaslini, Genoa, Italy
[6] Ist Nazl Ric Canc, I-16132 Genoa, Italy
[7] Ctr Eccellenza Ric Biomed, Genoa, Italy
来源：
AIDS | 2003年 / 17卷 / 02期
关键词：
D O I：
10.1097/00002030-200301240-00017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.
引用
收藏
页码：257 / 260
页数：4
相关论文
共 18 条
[1]  
Bertone S, 1999, EUR J IMMUNOL, V29, P23, DOI 10.1002/(SICI)1521-4141(199901)29:01<23::AID-IMMU23>3.0.CO
[2]  
2-Y
[3]   VIROLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF LONG-TERM SURVIVORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].
CAO, YZ ;
QIN, LM ;
ZHANG, LQ ;
SAFRIT, J ;
HO, DD .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :201-208
[4]   Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection [J].
Clerici, M ;
Balotta, C ;
Meroni, L ;
Ferrario, E ;
Riva, C ;
Trabattoni, D ;
Ridolfo, A ;
Villa, M ;
Shearer, GM ;
Moroni, M ;
Galli, M .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (11) :1053-1061
[5]   Differential disappearance of inhibitory natural killer cell receptors during HAART and possible impairment of HIV-1-specific CD8 cytotoxic T lymphocytes [J].
Costa, P ;
Rusconi, S ;
Mavilio, D ;
Fogli, M ;
Murdaca, G ;
Pende, D ;
Mingari, MC ;
Galli, M ;
Moretta, L ;
De Maria, A .
AIDS, 2001, 15 (08) :965-974
[6]   Multiple HLA-class I-specific inhibitory NK receptor expression and IL-4/IL-5 production by CD8+T-cell clones in HIV-1 infection [J].
De Maria, A ;
Mavilio, D ;
Costa, P ;
Dignetti, P ;
Fogli, M ;
Mingari, MC .
IMMUNOLOGY LETTERS, 2000, 72 (03) :179-182
[7]   Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: Impairment of specific cytolytic functions [J].
DeMaria, A ;
Ferraris, A ;
Guastella, M ;
Pilia, S ;
Cantoni, C ;
Polero, L ;
Mingari, MC ;
Bassetti, D ;
Fauci, AS ;
Moretta, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10285-10288
[8]   KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement [J].
Huard, B ;
Karlsson, L .
NATURE, 2000, 403 (6767) :325-328
[9]   BRIEF REPORT - ABSENCE OF INTACT NEF SEQUENCES IN A LONG-TERM SURVIVOR WITH NONPROGRESSIVE HIV-1 INFECTION [J].
KIRCHHOFF, F ;
GREENOUGH, TC ;
BRETTLER, DB ;
SULLIVAN, JL ;
DESROSIERS, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :228-232
[10]   Expression and function of NK cell receptors in CD8+ T cells [J].
McMahon, CW ;
Raulet, DH .
CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) :465-470
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