Socioeconomic Deprivation Does Not Impact Liver Transplantation Outcome for HCC: A Survival Analysis From a National Database

被引：6

作者：

Menahem, Benjamin ^{[1
,2
]}

Dejardin, Olivier ^{[2
,3
]}

Alves, Arnaud ^{[1
,2
]}

Launay, Ludivine ^{[2
]}

Lubrano, Jean ^{[1
,2
]}

Duvoux, Christophe ^{[4
]}

Laurent, Alexis ^{[5
,6
]}

Launoy, And Guy ^{[2
]}

Adam, Rene ^{[7
,8
]}

Anty, Rodolphe ^{[9
,10
,11
]}

Azoulay, Daniel ^{[21
]}

Bachellier, Philippe ^{[12
]}

Barbier, Louise ^{[13
]}

Besch, Camille ^{[13
]}

Boillot, Olivier ^{[14
,15
]}

Boleslawski, Emmanuel ^{[16
]}

Boudjema, Karim ^{[17
,18
,19
]}

Bouyabrine, Hassan ^{[20
]}

Buc, Emmanuel ^{[21
]}

Bucur, Petru ^{[13
]}

Cheisson, Gaelle ^{[22
]}

Cherqui, Daniel ^{[7
,8
]}

Chiche, Laurence ^{[23
,24
]}

Chirica, Mircea ^{[25
]}

Coily, Audrey ^{[26
,27
]}

Compagnon, Philippe ^{[5
]}

Conti, Filomena ^{[28
,29
]}

Decoster, Claire ^{[30
]}

Dharancy, Sebastian ^{[31
,32
]}

Di Martino, Vincent ^{[33
]}

Dondero, Federica ^{[34
]}

Dumortier, Jerome ^{[35
]}

Durand, Francois ^{[36
,37
,38
,39
]}

Faure, Stephanie ^{[40
]}

Francoz, Claire ^{[36
,37
,38
,39
]}

Giabicani, Mikhael ^{[41
]}

Girard, Edouard ^{[42
]}

Goumard, Claire ^{[28
,43
]}

Gregoire, Amaud ^{[44
,45
,46
]}

Gugenheim, Jean ^{[46
]}

Hardwigsen, Jean ^{[30
]}

Herrero, Astrid ^{[20
]}

Heyd, Bruno ^{[47
]}

Houseel-Debry, Pauline ^{[48
]}

Lahat, Eybn ^{[3
]}

Lambin, Geraldine ^{[49
]}

Langeron, Olivier ^{[49
]}

Lavoue, Sylvain ^{[53
]}

Lemains, Magali ^{[54
]}

Lim, Chetana ^{[3
]}

机构：

[1] CHU Caen, Dept Digest Surg, Caen, France

[2] Ctr Francois Baclesse, Pole Rech CHU Caen, INSERM U1086, Anticipe, Caen, France

[3] CHU Caen, Dept Res, Caen, France

[4] Hop Henri Mondor, AP HP, Dept Hepatol, Creteil, France

[5] Hop Henri Mondor, AP HP, Dept Hepatobiliary Pancreat Surg & Liver Transpla, Creteil, France

[6] INSERM, UMR 955, Creteil, France

[7] Hop Paul Brousse, AP HP, Ctr Hepatobiliaire, Dept Chirurg, Villejuif, France

[8] DHU Hepatinov, Villejuif, France

[9] CHU Nice, Ctr Digestif, Nice, France

[10] Equipe Complicat Hepat Obesite & Lalcoolisme, C3M, INSERM U1065, Nice, France

[11] Univ Cote dAzur, Nice, France

[12] Univ Strasbourg, Hop Hautepierre, Hop Univ Strasbourg,Pole Pathol Digest, Chirurg HepatoPancreato Bilaire & Transplantat He, Strasbourg, France

[13] Hop Univ Strasbourg, Serv Chirurg Hepatobiliaire & Transplantat, Hop Hautepierre, Strasbourg, France

[14] Hosp Civils Lyn, Federat Specialites Digest, Hop Edouard Herriot, Lyon, France

[15] Univ Claude Bernard Lyon 1, Lyon, France

[16] Hop Claude Huriez, Serv Chirurg Hepatobiliopancreat & Transplantat H, Lille, France

[17] CHU Rennes, Serv Chirurg Hepatobiliaire & Digest, Rennes, Ille & Vilaine, France

[18] Ctr invest Clin Rennes, INSERM, CIC 1414, Rennes, France

[19] Univ Rennes, Rennes, France

[20] Univ Montpellier, Serv Chirurg Hepat Pancreat & Transplantat, Coll Med, Hop St Eloi, Montpellier, France

[21] CHU Clermont Ferrand, Serv Chirurg Digest & Hepatobiliaire, Clermont Ferrand, France

[22] Hop Univ Paris Sud, Hop Bicetre, AP HP, Dept Danesthesie Reanimat Chirurg, Le Kremlin Bicetre, France

[23] CHU Bordeaux, Serv Chirurg Digest & Hepatobiliaire, Hop Haut Leveque, Bordeaux, France

[24] Univ Med Bordeaux, Bordeaux, France

[25] Univ Grenoble, Serv Chirurg Digest & Transplantat Hepat, Hop Michalon, Grenoble, France

[26] Hop Paul Brousse, AP HP, Ctr Hepatobiliaire, Unite Soins Intensifs Hepat, Villejuif, France

[27] Univ Paris Saclay, Unite 1193, Villejuif, France

[28] Sorbonne Univ, Univ Paris 06, UPMC, Paris, France

[29] Hop La Pitie Salpetriere, Unite Transplantat Hepat, Blvd Hop, Paris, France

[30] Hop La Timone, AP HP, Serv Chirurg Digest & Transplantat Hepat, Marseille, France

[31] CHU Lille, Serv Malad Appareil Digestif & Nutr, Lille, France

[32] LIRIC Lille Inflammat Res Int Ctr, INSERM 0995, Lille, France

[33] Hop Jean Minjoz, Serv Hepatol & Soins Intensifs Digestifs, Besancon, France

[34] Hop Paris Nord Val Seine, AP HP, Hop Beaujon, Dept Hosp Univ UNITY,Dept Chirurg Hepatobillopanc, Clichy, France

[35] Hosp Civils Lyon, Hop Edouard Heniot, Serv Hepatogastroenterol & Transplantat Hepat, Lyon, France

[36] Dept Hepatol & Soins Intensifs Hepat, Clichy, France

[37] INSERM U1149, Paris, France

[38] Hop Beaujon, Clichy, France

[39] Univ Paris Diderot, Paris, France

[40] CHU St Eloi, Serv Hepatol & Transplantat Hepat, Montpellier, France

[41] Hop Beaujon, HUPNVS, Dept Anesthesie Reanimat, Clichy, France

[42] Univ Grenoble Alpes, Serv Chirurg Urgence & Digest, Grenoble, France

[43] Hop La Pitie Salpetriere, Serv Chirurg Digest & Transplantat Hepat, Blvd Hop, Paris, France

[44] Univ Claude Bernard Lyon 1, Ctr Lyonnais Enseignement Simulat Sante, Lyon, France

[45] Hosp Civils Lyon, Hop Edouard Herriot, Serv Anesthesie Reanimat, Lyon, France

[46] Univ Nice Sophia Antipolis, Ctr Transplantat Hepat, Serv Chirurg Digest, Hop Archet, Nice, France

[47] Hop Jean Minjoz, Serv Chirurg Digest, Besancon, France

[48] CHU Rennes, Serv Malad Foie, Rennes, Ille & Vilaine, France

[49] CHU Clermont Ferrand, Serv Hepatogastroenterol, Clermont Ferrand, France

[50] Sorbonne Univ, Fac Med, Paris, France

来源：

TRANSPLANTATION | 2021年 / 105卷 / 05期

关键词：

HEPATOCELLULAR-CARCINOMA; GEOGRAPHICAL ACCESS; CANCER SURVIVAL; INDEX; CARE; DISEASE; HOSPITALIZATION; PARTICIPATION; INEQUALITIES; ASSOCIATION;

D O I：

10.1097/TP.0000000000003340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. To investigate the value of European deprivation index (EDI) and hepatocellular carcinoma (HCC) characteristics and their relationships with outcome after liver transplantation (LT). Methods. Patients undergoing LT for HCC were included from a national database (from "Agence de la Biomedecine" between 2006 and 2016. Characteristics of the patients were blindly extracted from the database. Thus, EDI was calculated in 5 quintiles and prognosis factors of survival were determined according to a Cox model. Results. Among the 3865 included patients, 33.9% were in the fifth quintile (quintile 1, N = 562 [14.5%]; quintile 2, N = 647 [16.7%]; quintile 3, N = 654 [16.9%]; quintile 4, N = 688 [17.8%]). Patients in each quintile were comparable regarding HCC history, especially median size of HCC, number of nodules of HCC and alpha-fetoprotein score. In the univariate analysis of the crude survival, having >2 nodules of HCC before LT and time on waiting list were associated with a higher risk of death (P < 0.0001 and P = 0.03, respectively). EDI, size of HCC, model for end-stage liver disease score, Child-Pugh score were not statistically significant in the crude and net survival. In both survival, time on waiting list and number of HCC >= 2 were independent factor of mortality after LT for HCC (P = 0.009 and 0.001, respectively, and P = 0.03 and 0.02, respectively). Conclusions. EDI does not impact overall survival after LT for HCC. Number of HCC and time on waiting list are independent prognostic factors of survival after LT for HCC.

引用

页码：1061 / 1068

页数：8

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