DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL THIENOPYRIMIDINES AND TRIAZOLOTHIENOPYRIMIDINES

被引：23

作者：

Mahmoud, Mahmoud R. ^{[1
]}

Abu El-Azm, Fatma S. M. ^{[1
]}

Ali, Amira T. ^{[1
]}

Ali, Yasmeen M. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Synthet Lab, Cairo 11566, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 08期

关键词：

Antimicrobial activity; 2-cyanoacetohydrazide; thienopyrimidines; triazolothienopyrimidines; SPECTRAL CHARACTERIZATION; DERIVATIVES; ANTAGONISTS; NITRILEN;

D O I：

10.1080/00397911.2014.999340

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.

引用

页码：982 / 992

页数：11

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