DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL THIENOPYRIMIDINES AND TRIAZOLOTHIENOPYRIMIDINES

被引：23

作者：

Mahmoud, Mahmoud R. ^{[1
]}

Abu El-Azm, Fatma S. M. ^{[1
]}

Ali, Amira T. ^{[1
]}

Ali, Yasmeen M. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Synthet Lab, Cairo 11566, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 08期

关键词：

Antimicrobial activity; 2-cyanoacetohydrazide; thienopyrimidines; triazolothienopyrimidines; SPECTRAL CHARACTERIZATION; DERIVATIVES; ANTAGONISTS; NITRILEN;

D O I：

10.1080/00397911.2014.999340

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.

引用

页码：982 / 992

页数：11

共 23 条

[1] SYNTHESIS OF SOME NEW TETRAHYDROBENZO[b] THIOPHENE DERIVATIVES AND TETRAHYDROBENZOTHIENOPYRIMIDINE DERIVATIVES UNDER MICROWAVE IRRADIATION [J].

Abdalha, A. A. ;

Abou El-Regal, M. K. ;

El-Kassaby, M. A. ;

Ali, A. T. .

SYNTHETIC COMMUNICATIONS, 2011, 41 (19) :2811-2821

[2] Synthesis of 2-mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, anti-inflammatory agents [J].

Alagarsamy, V. ;

Vijayakumar, S. ;

Solomon, V. Raja .

BIOMEDICINE & PHARMACOTHERAPY, 2007, 61 (05) :285-291

[3] Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-ones [J].

Alagarsamy, V. ;

Meena, S. ;

Ramseshu, K. V. ;

Solomon, V. R. ;

Thirumurugan, K. ;

Dhanabal, K. ;

Murugan, M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) :1293-1300

[4] Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives [J].

Ashalatha, B. V. ;

Narayana, B. ;

Raj, K. K. Vijaya ;

Kumari, N. Suchetha .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (05) :719-728

[5] Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents [J].

Chambhare, RV ;

Khadse, BG ;

Bobde, AS ;

Bahekar, RH .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (01) :89-100

[6] Synthesis of 7H-tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines and their reductive ring cleavage to 4-aminopyrrolo[2,3-d]pyrimidines [J].

Dave, CG ;

Shah, RD .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1998, 35 (06) :1295-1300

[7] Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines [J].

Donkor, IO ;

Li, H ;

Queener, SF .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (06) :605-611

[8]

El-Gazzar Abdel-Rahman B. A., 2007, Acta Pharmaceutica (Zagreb), V57, P395, DOI 10.2478/v10007-007-0032-6

[9] HETEROCYCLEN AUS CH-ACIDEN NITRILEN .7. 2-AMINO-THIOPHENE AUS ALPHA-OXO-MERCAPTANEN UND METHYLENAKTIVEN NITRILEN [J].

GEWALD, K .

CHEMISCHE BERICHTE-RECUEIL, 1965, 98 (11) :3571-&

[10] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL [J].

GEWALD, K ;

SCHINKE, E ;

BOTTCHER, H .

CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01) :94-&

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