Decision checkpoints in the thymus

被引：219
作者：
Carpenter, Andrea C. [1 ]
Bosselut, Remy [1 ]
机构：
[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期
基金：
美国国家卫生研究院;
关键词：
T-CELL-RECEPTOR; THYMOCYTE POSITIVE SELECTION; DELTA LINEAGE FATE; GAMMA-DELTA; ALPHA-BETA; ZINC-FINGER; TRANSCRIPTION FACTORS; CD8; LINEAGE; PHOSPHATIDYLINOSITOL; 3-KINASE; INTERLEUKIN-7; RECEPTOR;
D O I：
10.1038/ni.1887
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The development of T cells in the thymus involves several differentiation and proliferation events, during which hematopoietic precursors give rise to T cells ready to respond to antigen stimulation and undergo effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of alpha beta and gamma delta lineage cells and the elaboration of the alpha beta T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions.
引用
收藏
页码：666 / 673
页数：8
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