Cytochrome p450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen

被引：125
作者：
Jalas, JR
Hecht, SS
Murphy, SE
机构：
[1] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 2005年 / 18卷 / 02期
关键词：
D O I：
10.1021/tx049847p
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
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页码：95 / 110
页数：16
相关论文
共 102 条
[1]  
[Anonymous], ORSA J COMPUT
[2]   Expression and localization of CYP3A4 and CYP3A5 in human lung [J].
Anttila, S ;
Hukkanen, J ;
Hakkola, J ;
Stjernvall, T ;
Beaune, P ;
Edwards, RJ ;
Boobis, AR ;
Pelkonen, O ;
Raunio, H .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1997, 16 (03) :242-249
[3]   5 OF 12 FORMS OF VACCINIA VIRUS-EXPRESSED HUMAN HEPATIC CYTOCHROME-P450 METABOLICALLY ACTIVATE AFLATOXIN-B1 [J].
AOYAMA, T ;
YAMANO, S ;
GUZELIAN, PS ;
GELBOIN, HV ;
GONZALEZ, FJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4790-4793
[4]  
Ariyoshi N, 2002, CANCER EPIDEM BIOMAR, V11, P890
[5]   Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung [J].
Atalla, A ;
Maser, E .
TOXICOLOGY, 1999, 139 (1-2) :155-166
[6]   Investigation of the role of lipoxygenase in bioactivation of 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK) in human lung [J].
Bedard, LL ;
Smith, GBJ ;
Reid, KR ;
Petsikas, D ;
Massey, TE .
CHEMICAL RESEARCH IN TOXICOLOGY, 2002, 15 (10) :1267-1273
[7]   Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine [J].
Carmella, SG ;
Le, KA ;
Upadhyaya, P ;
Hecht, SS .
CHEMICAL RESEARCH IN TOXICOLOGY, 2002, 15 (04) :545-550
[8]  
Carmella SG, 1999, CANCER RES, V59, P3602
[9]   MODULATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1 BUTANONE DEMETHYLATION AND DENITROSATION BY RAT-LIVER MICROSOMES [J].
CASTONGUAY, A ;
PEPIN, P ;
BRIERE, N .
CANCER LETTERS, 1991, 59 (01) :67-74
[10]  
Chen C, 1999, CANCER EPIDEM BIOMAR, V8, P317
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