Addiction is a chronic relapsing disorder with devastating personal, societal, and economic consequences. In humans, early-life adversity (ELA) such as trauma, neglect, and resource scarcity are linked with increased risk of later-life addiction, but the brain mechanisms underlying this link are still poorly understood. Here, we focus on data from rodent models of ELA and addiction, in which causal effects of ELA on later-life responses to drugs and the neurodevelopmental mechanisms by which ELA increases vulnerability to addiction can be determined. We first summarize evidence for a link between ELA and addiction in humans, then describe how ELA is commonly modeled in rodents. Since addiction is a heterogeneous disease with many individually varying behavioral aspects that may be impacted by ELA, we next discuss common rodent assays of addiction-like behaviors. We then summarize the specific addiction-relevant behavioral phenotypes caused by ELA in male and female rodents and discuss some of the underlying changes in brain reward and stress circuits that are likely responsible. By better understanding the behavioral and neural mechanisms by which ELA promotes addiction vulnerability, we hope to facilitate development of new approaches for preventing or treating addiction in those with a history of ELA.
机构:
Howard Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Howard Univ, Dept Psychiat & Behav Sci, Coll Med, Washington, DC 20059 USAHoward Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Bassey, Rosemary B.
;
Gondre-Lewis, Marjorie C.
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机构:
Howard Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Howard Univ, Dept Psychiat & Behav Sci, Coll Med, Washington, DC 20059 USAHoward Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Bath, Kevin G.
;
Nitenson, Arielle Schilit
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h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Nitenson, Arielle Schilit
;
Lichtman, Ezra
论文数: 0引用数: 0
h-index: 0
机构:
Yale Sch Med, New Haven, CT 06510 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Lichtman, Ezra
;
Lopez, Chelsea
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Lopez, Chelsea
;
Chen, Whitney
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurosci, San Francisco, CA 94158 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Chen, Whitney
;
Gallo, Meghan
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Gallo, Meghan
;
Goodwill, Haley
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h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Goodwill, Haley
;
Manzano-Nieves, Gabriela
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h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
机构:
Univ Michigan, Dept Psychol, Ann Arbor, MI USA
Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Dept Psychol, Ann Arbor, MI USA
Becker, Jill B.
;
Chartoff, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USAUniv Michigan, Dept Psychol, Ann Arbor, MI USA
机构:
Howard Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Howard Univ, Dept Psychiat & Behav Sci, Coll Med, Washington, DC 20059 USAHoward Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Bassey, Rosemary B.
;
Gondre-Lewis, Marjorie C.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
Howard Univ, Dept Psychiat & Behav Sci, Coll Med, Washington, DC 20059 USAHoward Univ, Dept Anat, Coll Med, 520 W St NW, Washington, DC 20059 USA
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Bath, Kevin G.
;
Nitenson, Arielle Schilit
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Nitenson, Arielle Schilit
;
Lichtman, Ezra
论文数: 0引用数: 0
h-index: 0
机构:
Yale Sch Med, New Haven, CT 06510 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Lichtman, Ezra
;
Lopez, Chelsea
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Lopez, Chelsea
;
Chen, Whitney
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurosci, San Francisco, CA 94158 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Chen, Whitney
;
Gallo, Meghan
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Gallo, Meghan
;
Goodwill, Haley
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
Goodwill, Haley
;
Manzano-Nieves, Gabriela
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Neurosci, Box 1821, Providence, RI 02912 USABrown Univ, Dept Cognit Linguist & Psychol Sci, Box 1821, Providence, RI 02912 USA
机构:
Univ Michigan, Dept Psychol, Ann Arbor, MI USA
Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Dept Psychol, Ann Arbor, MI USA
Becker, Jill B.
;
Chartoff, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USAUniv Michigan, Dept Psychol, Ann Arbor, MI USA