Recent updates on grading and classification of neuroendocrine tumors

被引：162

作者：

Kim, Joo Young ^{[1
]}

Hong, Seung-Mo ^{[2
]}

Ro, Jae Y. ^{[3
]}

机构：

[1] Korea Univ, Anam Hosp, Coll Med, Dept Pathol, Seoul, South Korea

[2] Univ Ulsan, Dept Pathol, Coll Med, Asan Med Ctr, Seoul, South Korea

[3] Cornell Univ, Weill Med Coll, Houston Methodist Hosp, Dept Pathol & Genom Med, 1515 Fannin St, Houston, TX 77030 USA

来源：

ANNALS OF DIAGNOSTIC PATHOLOGY | 2017年 / 29卷

基金：

新加坡国家研究基金会;

关键词：

Neuroendocrine tumors; Carcinoid; Grade; Classification; TRANSCRIPTION FACTOR-I; KI67 PROLIFERATIVE INDEX; SMALL-CELL CARCINOMAS; RECTAL NEUROENDOCRINE; GASTROENTEROPANCREATIC SYSTEM; PATHOLOGICAL CLASSIFICATION; 34-BETA-E12; EXPRESSION; PULMONARY CARCINOIDS; CLINICAL BEHAVIOR; ENDOCRINE TUMOR;

D O I：

10.1016/j.anndiagpath.2017.04.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neuroendocrine tumors (NETs) are originating from neuroendocrine cells in diffuse endocrine systems. NETs are diagnosed by characteristic histologic features and immunoprofiles. Recent 2010 WHO classification for gastroenteropancreatic NETs introduced grading system based on mitotic count and Ki-67 proliferation index. Gastroenteropancreatic NETs are classified as NET grade 1, NET grade 2, and neuroendocrine carcinoma (NET grade 3). However, the carcinoid is still used in classification of NETs of the lung and uterine cervix. Some issues with grading system such as methodologies for evaluation of Ki-67 index and subclassification of neuroendocrine carcinoma (NET grade 3) are arising. The importance of Ki-67 labeling index is emerging in differential diagnosis of lung carcinoids. In this review, we focus on recent grading and classification of NETs and related issues in various organs, including gastrointestinal tract, pancreas, lung, and female reproductive organs.

引用

页码：11 / 16

页数：6

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