Evaluation of a computer-aided method for measuring the Cobb angle on chest X-rays

被引:78
作者
Pan, Yaling [1 ]
Chen, Qiaoran [2 ]
Chen, Tongtong [1 ]
Wang, Hanqi [1 ]
Zhu, Xiaolei [1 ]
Fang, Zhihui [3 ]
Lu, Yong [1 ]
机构
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiol, Shanghai 200025, Peoples R China
[2] Shenzhen Yi Yuan Intelligence Co Ltd, Shenzhen 518064, Guangdong, Peoples R China
[3] Shanghai Qual Creat Intelligent Technol Co Ltd, Shanghai 200050, Peoples R China
关键词
Chest X-rays; Cobb angle; Computer-aided; Deep learning; Scoliosis; RELIABILITY-ANALYSIS; SCOLIOSIS;
D O I
10.1007/s00586-019-06115-w
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives To automatically measure the Cobb angle and diagnose scoliosis on chest X-rays, a computer-aided method was proposed and the reliability and accuracy were evaluated. Methods Two Mask R-CNN models as the core of a computer-aided method were used to separately detect and segment the spine and all vertebral bodies on chest X-rays, and the Cobb angle of the spinal curve was measured from the output of the Mask R-CNN models. To evaluate the reliability and accuracy of the computer-aided method, the Cobb angles on 248 chest X-rays from lung cancer screening were measured automatically using a computer-aided method, and two experienced radiologists used a manual method to separately measure Cobb angles on the aforementioned chest X-rays. Results For manual measurement of the Cobb angle on chest X-rays, the intraclass correlation coefficients (ICC) of intra- and inter-observer reliability analysis was 0.941 and 0.887, respectively, and the mean absolute differences were < 3.5 degrees. The ICC between the computer-aided and manual methods for Cobb angle measurement was 0.854, and the mean absolute difference was 3.32 degrees. These results indicated that the computer-aided method had good reliability for Cobb angle measurement on chest X-rays. Using the mean value of Cobb angles in manual measurements > 10 degrees as a reference standard for scoliosis, the computer-aided method achieved a high level of sensitivity (89.59%) and a relatively low level of specificity (70.37%) for diagnosing scoliosis on chest X-rays. Conclusion The computer-aided method has potential for automatic Cobb angle measurement and scoliosis diagnosis on chest X-rays. Graphic abstract These slides can be retrieved under Electronic Supplementary Material.
引用
收藏
页码:3035 / 3043
页数:9
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