The squalestatins:: tricyclic 3,4-β-lactone and 3,4-oxetane systems

被引：1
作者：
Cox, B
Morley, N
Procopiou, PA
Sharratt, PJ
Watson, NS
Wild, D
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Med Chem 1, Stevenage SG1 2NY, Herts, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Med Chem 2, Stevenage SG1 2NY, Herts, England
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期
关键词：
D O I：
10.1016/S0040-4039(00)01286-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Squalestatin 3,4-beta-lactone-4,5-dimethyl ester (8) was reductively ring-opened to yield squalestatin 3-hydroxymethyl-4,5-dimethyl ester (6) using mild reducing conditions (sodium borohydride). Similarly squalestatin 3,4-oxetane-4,5-dimethyl ester (10) was found to ring-open to 3-iodomethyl squalestatin (15) under the conditions used to cleave the methyl ester functions (lithium iodide/2,4,6-trimethylpyridine). (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：7547 / 7550
页数：4
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