Synthesis and Characterization of γ-Fe2O3@HAp@β-CD Core-Shell Nanoparticles As a Novel Magnetic Nanoreactor and Its Application in the One-Pot Preparation of β-azido Alcohols, β-nitro Alcohols, and β-cyanohydrins

In this study, beta-cyclodextrin(beta-CD) supported, hydroxyapatite encapsulated gamma-Fe2O3(gamma-Fe2O3@HAp@beta-CD) was successfully prepared and evaluated as a solid-liquid phase transfer catalyst and also a molecular host system and nanoreactor for the nucleophilic ring opening of epoxides in water for the preparation of beta-azido alcohols, beta-nitro alcohols, and beta-cyanohydrins. The catalyst was characterized with FT-IR, XRD, TGA and SEM. This procedure offers several advantages including excellent regioselectivity, high yields, short reaction times, recyclable catalyst, easy separation of the catalyst through external magnet, and easy work-up.