Sex-related Differences in Inflammatory Bowel Diseases: The Potential Role of Sex Hormones

被引：37

作者：

Xu, Leiqi ^{[1
]}

Huang, Gang ^{[1
]}

Cong, Yingzi ^{[2
,3
]}

Yu, Yanbo ^{[1
]}

Li, Yanqing ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Gastroenterol, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China

[2] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX USA

[3] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA

来源：

INFLAMMATORY BOWEL DISEASES | 2022年 / 28卷 / 11期

基金：

中国国家自然科学基金;

关键词：

sex hormones; sex difference; inflammatory bowel disease; ESTROGEN-RECEPTOR-BETA; GENDER-RELATED DIFFERENCES; CROHNS-DISEASE; TESTOSTERONE REPLACEMENT; ORAL-CONTRACEPTIVES; IMMUNE-RESPONSE; CELL RESPONSES; T-CELLS; IN-VIVO; PROGESTERONE;

D O I：

10.1093/ibd/izac094

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD), characterized by chronic inflammation of the gastrointestinal tract, is a global health care problem. Compelling evidence shows sex differences regarding the prevalence, pathophysiology, clinical presentation, and treatment outcome of IBD. Sex hormones, including estrogen, progesterone, and androgen, have been proposed to have a role in the pathogenesis of sexual dimorphism in IBD. Clinical and experimental data support the modulatory effects of sex hormones on various clinical characteristics of the disease, including intestinal barrier dysfunction and mucosal immune activation. Additionally, the potential role of sex hormones in the modulation of gut microbiota is attracting increasing attention. Here, we discuss the sex dimorphic disease profile and address the potential mechanisms involved in the sex-specific pathogenesis of IBD. Improved understanding of these sex differences in the clinic could improve the knowledge of patients with IBD with heterogeneous disease profiles.

引用

页码：1766 / 1775

页数：10

共 100 条

[1] Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease [J].

Abhyankar, A. ;

Ham, M. ;

Moss, A. C. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 38 (05) :460-466

[2] Short-term oral exposure to low doses of nano-sized TiO2 and potential modulatory effects on intestinal cells [J].

Ammendolia, Maria Grazia ;

Iosi, Francesca ;

Maranghi, Francesca ;

Tassinari, Roberta ;

Cubadda, Francesco ;

Aureli, Federica ;

Raggi, Andrea ;

Superti, Fabiana ;

Mantovani, Alberto ;

De Berardis, Barbara .

FOOD AND CHEMICAL TOXICOLOGY, 2017, 102 :63-75

[3] NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis [J].

Arruvito, Lourdes ;

Giulianelli, Sebastian ;

Flores, Ana C. ;

Paladino, Natalia ;

Barboza, Marcos ;

Lanari, Claudia ;

Fainboim, Leonardo .

JOURNAL OF IMMUNOLOGY, 2008, 180 (08) :5746-5753

[4] Nutrient availability, the microbiome, and intestinal transport during pregnancy [J].

Astbury, Stuart ;

Mostyn, Alison ;

Symonds, Michael E. ;

Bell, Rhonda C. .

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2015, 40 (11) :1100-1106

[5] Epidemiology of Pediatric Inflammatory Bowel Disease: A Systematic Review of International Trends [J].

Benchimol, Eric I. ;

Fortinsky, Kyle J. ;

Gozdyra, Peter ;

Van den Heuvel, Meta ;

Van Limbergen, Johan ;

Griffiths, Anne M. .

INFLAMMATORY BOWEL DISEASES, 2011, 17 (01) :423-439

[6]

Bernstein CN, 2001, AM J GASTROENTEROL, V96, P1116

[7] Gastrointestinal symptoms before and during menses in women with IBD [J].

Bernstein, M. T. ;

Graff, L. A. ;

Targownik, L. E. ;

Downing, K. ;

Shafer, L. A. ;

Rawsthorne, P. ;

Bernstein, C. N. ;

Avery, L. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2012, 36 (02) :135-144

[8] Female patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity A subgroup analysis of a large multi-centre, prospective, internet-based study [J].

Blumenstein, I. ;

Herrmann, E. ;

Filmann, N. ;

Zosel, C. ;

Tacke, W. ;

Bock, H. ;

Dignass, A. ;

Hartmann, F. ;

Zeuzem, S. ;

Stein, J. ;

Schroeder, O. .

JOURNAL OF CROHNS & COLITIS, 2011, 5 (03) :203-210

[9] Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats [J].

Braniste, Viorica ;

Jouault, Aurore ;

Gaultier, Eric ;

Polizzi, Arnaud ;

Buisson-Brenac, Claire ;

Leveque, Mathilde ;

Martin, Pascal G. ;

Theodorou, Vassilia ;

Fioramonti, Jean ;

Houdeau, Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :448-453

[10] New-onset ulcerative colitis in pregnancy associated to toxic megacolon and sudden fetal decompensation: Case report and literature review [J].

Brunelli, Roberto ;

Perrone, Seila ;

Perrone, Giuseppina ;

Galoppi, Paola ;

De Stefano, Maria G. ;

Maragno, Anna M. ;

Cesarini, Monica ;

De Carolis, Aurora ;

Masselli, Gabriele ;

Vernia, Piero .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2019, 45 (07) :1215-1221

← 1 2 3 4 5 6 7 8 9 10 →