Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

被引：44

作者：

Cosson, A. ^{[1
,2
,3
]}

Chapiro, E. ^{[1
,2
,4
]}

Bougacha, N. ^{[1
,2
,3
]}

Lambert, J. ^{[5
]}

Herbi, L. ^{[1
,2
,3
]}

Cung, H-A ^{[4
]}

Algrin, C.

Keren, B. ^{[6
]}

Damm, F. ^{[7
]}

Gabillaud, C. ^{[4
]}

Brunelle-Navas, M-N ^{[1
,2
,3
,4
]}

Davi, F. ^{[1
,2
,4
]}

Merle-Beral, H. ^{[1
,2
,4
]}

Le Garff-Tavernier, M. ^{[1
,2
,4
]}

Roos-Weil, D. ^{[7
]}

Choquet, S. ^{[4
]}

Uzunov, M. ^{[4
]}

Morel, V. ^{[4
]}

Leblond, V. ^{[4
]}

Maloum, K. ^{[4
]}

Lepretre, S. ^{[8
]}

Feugier, P. ^{[9
]}

Lesty, C. ^{[4
]}

Lejeune, J. ^{[5
]}

Sutton, L. ^{[10
]}

Landesman, Y. ^{[11
]}

Susin, S. A. ^{[1
,2
,3
]}

Nguyen-Khac, F. ^{[1
,2
,4
]}

机构：

[1] INSERM UMR S 1138, Ctr Rech Cordeliers, Cell Death & Drug Resistance Lymphoproliferat Dis, Paris, France

[2] UPMC Univ Paris 06, Sorbonne Univ, UMR S 1138, Ctr Rech Cordeliers, Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, UMR S 1138, Ctr Rech Cordeliers, Paris, France

[4] GH Pitie Salpetriere, Serv Hematol Biol, Paris, France

[5] Hop St Louis, Serv Biostat & Informat Med, Paris, France

[6] GH Pitie Salpetriere, Dept Genet, Paris, France

[7] Inst Gustave Roussy, INSERM U1170, Villejuif, France

[8] Hop Becquerel, Dept Hematol, Rouen, France

[9] Hop Brabois, Pole Hematol, Vandoeuvre Les Nancy, France

[10] Hop Argenteuil, Serv Hematol, Argenteuil, France

[11] Karyopharm Therapeut, Newton, MA USA

来源：

LEUKEMIA | 2017年 / 31卷 / 07期

关键词：

RECURRENT GENOMIC ALTERATIONS; NUCLEAR EXPORT; CLL PATIENTS; MUTATIONS; CANCER; TRIAL; SF3B1; CELLS;

D O I：

10.1038/leu.2017.100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1625 / 1629

页数：6

共 18 条

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