Smoking and Drinking Adjusted Association between Head and Neck Cancers and Oral Health Status Related to Periodontitis: a Meta-Analysis

被引:2
作者
Vu, Huong [1 ]
Shin, Yoo-Jin [1 ,2 ]
Kong, Mi-Sun [1 ]
Kim, Hyun-Duck [1 ,3 ]
机构
[1] Seoul Natl Univ, Sch Dent, Dept Prevent & Social Dent, Seoul, South Korea
[2] Seoul Natl Univ, Dept Oral & Maxillofacial Surg, Dent Hosp, Seoul, South Korea
[3] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
Meta-analysis; Oral Health Status; Periodontitis; Head and Neck Cancer; SQUAMOUS-CELL CARCINOMA; RISK-FACTORS; CHRONIC INFLAMMATION; SOUTHERN INDIA; DISEASE; EPIDEMIOLOGY; DENTITION; HYGIENE; PROFESSIONALS; INFECTIONS;
D O I
10.3346/jkms.2021.36.e98
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Not so many reports about the association between head and neck cancer (HNC) and oral health status related to periodontitis (OHS-P) has been published in different countries with different methods. So, there is a need for an extensive meta-analysis with the total articles published until 2020. Hence, this study aimed to estimate the association between HNC and OHS-P through a meta-analysis. Methods: Based on Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines, 22 studies were selected through PubMed and Cochrane Library databases. Meta-analysis using them was performed to evaluate the association. The risk of bias assessment using the Newcastle-Ottawa Scale (NOS) was applied to evaluate the quality of non-randomized studies. Publication bias was evaluated by funnel plot and Egger's regression test. Results: Since heterogeneity was significant (I-2 = 88%, P < 0.001), we adopted the random effect model for 22 studies. Those with bad OHS-P, compared to those with good OHS-P, were more likely to have the risk of HNC by 2.4 times (odds ratio [OR], 2.42; 95% confidence interval [CI], 1.88-3.13) for random effect model. The association included publication bias (Egger's regression, P value < 0.001). The association among five studies (I-2 = 39%, P = 0.16) using alveolar bone loss (ABL) or clinical attachment level (CAL) for assessing periodontitis increased to OR of 3.85 (CI, 3.04-4.88) in the fixed effect model without publication bias (Egger's regression, P = 0.66). Moreover, the association was higher in 10 fair or good NOS studies (OR, 3.08) and in 7 Asian studies (OR, 2.68), which were from the fixed model without publication bias. Conclusion: Our meta-analysis showed that bad OHS-P was associated with the risk of HNC. The association was stronger in studies using ABL or CAL for assessing periodontitis.
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页数:16
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