Repurposing of Anticancer Drugs Expands Possibilities for Antiviral and AntiInflammatory Discovery in COVID-19

被引：23

作者：

Aldea, Mihaela ^{[1
]}

Michot, Jean-Marie ^{[2
]}

Danlos, Francois-Xavier ^{[3
,4
]}

Ribas, Antoni ^{[5
]}

Soria, Jean-Charles ^{[2
,4
]}

机构：

[1] Gustave Roussy, Dept Med Oncol, Villejuif, France

[2] Gustave Roussy, Drug Dev Dept, Villejuif, France

[3] Gustave Roussy, INSERM U1015, Villejuif, France

[4] Paris Saclay Univ, St Aubin, France

[5] Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90024 USA

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 06期

关键词：

CLINICAL CHARACTERISTICS; CANCER; PREVALENCE; INHIBITORS; CELLS;

D O I：

10.1158/2159-8290.CD-21-0144

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 2020, the COVID-19 pandemic led to an unprecedented destabilization of the world's health and economic systems. The rapid spread and life-threatening consequences of COVID-19 have imposed testing of repurposed drugs, by investigating interventions already used in other indications, including anticancer drugs. The contours of anticancer drug repurposing have been shaped by similarities between the pathogenesis of COVID-19 and malignancies, including abnormal inflammatory and immunologic responses. In this review, we discuss the salient positive and negative points of repurposing anticancer drugs to advance treatments for COVID-19. significance: Targeting anti-inflammatory pathways with JAK/STAT inhibitors or anticytokine therapies aiming to curb COVID-19-related cytokine storm, using antiangiogenic drugs to reduce vascular abnormalities or immune-checkpoint inhibitors to improve antiviral defenses, could be of value in COVID-19. However, conflicting data on drug efficacy point to the need for better patient selection and biomarker studies.

引用

页码：1336 / 1344

页数：9

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