SARS-CoV-2 and the Nucleus

被引：14

作者：

Chen, Mengqi ^{[1
]}

Ma, Yue ^{[1
]}

Chang, Wakam ^{[1
]}

机构：

[1] Univ Macau, Fac Hlth Sci, Dept Biomed Sci, Taipa, Macao, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 12期

关键词：

SARS-CoV-2; nuclear transport; innate immunity; epigenetics; cilia; DNA damage; NUCLEOCAPSID PROTEIN; GENE-EXPRESSION; CELL-NUCLEUS; LAMIN-A/C; MECHANISMS; LANDSCAPE; IMPORT; CORONAVIRUSES; TRANSLOCATION; INHIBITION;

D O I：

10.7150/ijbs.72482

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ongoing COVID-19 pandemic is caused by an RNA virus, SARS-CoV-2. The genome of SARS-CoV-2 lacks a nuclear phase in its life cycle and is replicated in the cytoplasm. However, interfering with nuclear trafficking using pharmacological inhibitors greatly reduces virus infection and virus replication of other coronaviruses is blocked in enucleated cells, suggesting a critical role of the nucleus in virus infection. Here, we summarize the alternations of nuclear pathways caused by SARS-CoV-2, including nuclear translocation pathways, innate immune responses, mRNA metabolism, epigenetic mechanisms, DNA damage response, cytoskeleton regulation, and nuclear rupture. We consider how these alternations contribute to virus replication and discuss therapeutic treatments that target these pathways, focusing on small molecule drugs that are being used in clinical studies.

引用

页码：4731 / 4743

页数：13

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