Recent advances in screening of enzymes inhibitors based on capillary electrophoresis

被引：41

作者：

Cheng, Mengxia

Chen, Zilin ^{[1
]}

机构：

[1] Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL ANALYSIS | 2018年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Capillary electrophoresis; Enzyme inhibitor screening; Pre-capillary enzyme assays; Electrophoretically mediated microanalysis; Immobilized enzyme microreactor; TRADITIONAL CHINESE MEDICINES; AMINO-ACID OXIDASE; PARTIALLY FILLED CAPILLARY; TANDEM MASS-SPECTROMETRY; MEDIATED MICROANALYSIS; IMMOBILIZED ENZYME; DRUGGABLE GENOME; DERIVATIZATION REACTIONS; TYROSINASE INHIBITORS; MOLECULAR DOCKING;

D O I：

10.1016/j.jpha.2018.05.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Capillary electrophoresis with many advantages plays an important role in pharmaceutical analysis and drug screening. This review gives an overview on the recent advances in the developments and applications of capillary electrophoresis in the field of enzyme inhibitor screening. The period covers 2013 to 2017. Both the pre-capillary enzyme assays and in-capillary enzyme assays which include electrophoretically mediated microanalysis (EMMA) and immobilized enzyme microreactor (IMER) are summarized in this article. (C) 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.

引用

页码：226 / 233

页数：8

共 67 条

[1] Neuronal nicotinic receptors: A perspective on two decades of drug discovery research [J].