Effects of natural polysaccharide addition on drug release from calcium-induced alginate gel beads

被引：21
作者：
Murata, Y [1 ]
Tsumoto, K [1 ]
Kofuji, K [1 ]
Kawashima, S [1 ]
机构：
[1] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 02期
关键词：
alginate gel bead; chitin; alginic acid; hydrocortisone;
D O I：
10.1248/cpb.51.218
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca.
引用
收藏
页码：218 / 220
页数：3
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