Decrease in Adenylyl Cyclase V/VI and Increase in Phosphodiesterase 4D5 Expression and Activities in Smooth Muscle lead to Decrease in cAMP levels, Smooth Muscle Relaxation and Gastrointestinal Motility in Diabetes

被引：0

|

作者：

Mahavadi, Sunila ^{[1
]}

Kendig, Derek ^{[2
]}

Grider, John R. ^{[1
]}

Murthy, Karnam S. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, VCU Program Enter Neuromuscular Sci, Physiol & Biophys, Richmond, VA USA

[2] Loyola Univ Maryland, Biol, Baltimore, MD USA

来源：

FASEB JOURNAL | 2017年 / 31卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1047.7

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页数：2

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[2] Down-regulation of caveolin-1 in smooth muscle from TNBS-induced colitis mediates the increase in phosphodiesterase-5 activity and decrease in cGMP-induced muscle relaxation
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[3] Dual mechanism for inhibition of cAMP by interleukin-1β in smooth muscle:: Inhibitory S-nitrosylation of adenylyl cyclase V/VI via iNOS-derived NO and stimulation of PDE4 expression and activity
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[4] Decrease in RGS4 Expression via miR-1 and Increase in CPI-17 Expression via miR-145 in Diabetes Lead to Augmentation of Ca2+-Dependent Initial Contraction and Ca2+-Independent Sustained Contraction, Respectively, in Gastrointestinal Smooth Muscle
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FASEB JOURNAL, 2017, 31