Synthesis, structures and biological activity of some 4-amino-3-cinnoline-carboxylic acid derivatives .3. 1,3-oxazino[5,4-c]cinnolines and pyrimido[5,4-c]cinnolines

被引：0

作者：

Stanczak, A ^{[1
]}

Pakulska, W ^{[1
]}

机构：

[1] MED UNIV LODZ, DEPT PHARMACODYNAM, PL-90151 LODZ, POLAND

来源：

PHARMAZIE | 1997年 / 52卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with acid anhydrides to corresponding 1,3-oxazino[5,4-c]cinnolines 2. The reactions of 1,3-oxazino[5,4-c]cinnolines 2 with amines, hydrazine, hydroxylamine, alanine ethyl ester provided pyrimido[5,4-c]cinnolines 3, 4. Selected 3-substituted 3-methylpyrimido[5,4-c]cinnolin-4(3 H)-ones have been screened for CNS activity.

引用

页码：838 / 843

页数：6

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