Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in a Heart Transplant Recipient Treated by Substitution of Cyclosporine A with Tacrolimus

被引：8

作者：

Oda, Noboru ^{[1
,2
]}

Kato, Tomoko S. ^{[1
,2
]}

Hanatani, Akihisa ^{[1
,2
]}

Niwaya, Kazuo ^{[3
]}

Nakatani, Takeshi ^{[2
]}

Ishibashi-Ueda, Hatsue ^{[4
]}

Kitamura, Soichiro ^{[3
]}

Hashimura, Kazuhiko ^{[1
]}

Kitakaze, Masafumi ^{[1
]}

Komamura, Kazuo ^{[1
,2
]}

机构：

[1] Natl Cardiovasc Ctr, Dept Cardiovasc Med, Suita, Osaka 565, Japan

[2] Natl Cardiovasc Ctr, Dept Organ Transplantat, Suita, Osaka 565, Japan

[3] Natl Cardiovasc Ctr, Dept Cardiovasc Surg, Suita, Osaka 565, Japan

[4] Natl Cardiovasc Ctr, Dept Pathol, Suita, Osaka 565, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 11期

关键词：

heart transplant; immunosuppression; complications; reversible posterior leukoencephalopathy; syndrome; calcineurin inhibitors; CLINICAL SPECTRUM; ENCEPHALOPATHY;

D O I：

10.2169/internalmedicine.49.3012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reversible posterior leukoencephalopathy syndrome (RPLS) is one of the important adverse events following organ transplantation, associated with calcineurin inhibitors (CNIs). We describe a case of 54-year-old woman, who was diagnosed with RPLS within weeks after transplantation. Considering the risk of causing fatal rejection by discontinuation of CNIs, the immunosuppressive regimen of the patient was switched from a cyclosporine A-based regimen to a tacrolimus-based regimen. The patient recovered rapidly from RPLS following the switch to tacrolimus. This case demonstrated that not only discontinuation but also a substitution of CNIs would be a valid treatment option for RPLS in transplant recipients.

引用

页码：1013 / 1016

页数：4

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