Inside job: Staphylococcus aureus host-pathogen interactions

被引：138

作者：

Horn, Jessica ^{[1
]}

Stelzner, Kathrin ^{[1
]}

Rudel, Thomas ^{[1
]}

Fraunholz, Martin ^{[1
]}

机构：

[1] Univ Wurzburg, Bioctr, Chair Microbiol, D-97074 Wurzburg, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2018年 / 308卷 / 06期

关键词：

Staphylococcus aureus; Invasion; Phagosomal escape; Intracellular persistence; Autophagy; Trojan horse phenotype; Dissemination; Host cell death induction; SMALL-COLONY VARIANTS; PANTON-VALENTINE LEUKOCIDIN; VIRULENCE DETERMINANT PRODUCTION; SIGMA-FACTOR SIGMA(S); NF-KAPPA-B; CELL-DEATH; ALPHA-TOXIN; GENE-EXPRESSION; 2-COMPONENT SYSTEM; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.ijmm.2017.11.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of diseases. Recent research established that once phagocytosed by neutrophils and macrophages, a certain percentage of S. aureus is able to survive within these phagocytes which thereby even may contribute to dissemination of the pathogen. S. aureus further induces its uptake by otherwise non-phagocytic cells and the ensuing intracellular cytotoxicity is suggested to lead to tissue destruction, whereas bacterial persistence within cells is thought to lead to immune evasion and chronicity of infections. We here review recent work on the S. aureus host pathogen interactions with a focus on the intracellular survival of the pathogen.

引用

页码：607 / 624

页数：18

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