Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

被引：63

作者：

Chatzipanagis, Konstantinos ^{[1
]}

Iafisco, Michele ^{[2
]}

Roncal-Herrero, Teresa ^{[1
]}

Bilton, Matthew ^{[1
,3
]}

Tampieri, Anna ^{[2
]}

Kroger, Roland ^{[1
]}

Manuel Delgado-Lopez, Jose ^{[4
]}

机构：

[1] Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England

[2] Natl Res Council CNR, Inst Sci & Technol Ceram ISTEC, Faenza, Italy

[3] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[4] CSIC UGR, IACT, Lab Estudios Cristalog, Granada, Spain

来源：

CRYSTENGCOMM | 2016年 / 18卷 / 18期

基金：

欧盟第七框架计划; 英国工程与自然科学研究理事会;

关键词：

RAMAN MICROSPECTROSCOPY; BONE APATITE; HYDROXYAPATITE; MINERALIZATION; PRECIPITATION; BIOMATERIALS; NUCLEATION; CONVERSION; KINETICS; SITES;

D O I：

10.1039/c6ce00521g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

引用

页码：3170 / 3173

页数：4

共 33 条

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